173989-76-9

Basic information

• Product Name: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid
• Synonyms: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid
• CAS NO: 173989-76-9
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.24782
• Mol File: 173989-76-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 373.416°C at 760 mmHg
• Flash Point: 179.636°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid(173989-76-9)
• EPA Substance Registry System: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid(173989-76-9)

Safety Data

• Hazardous Substances Data: 173989-76-9(Hazardous Substances Data)

Usage

General Description

The chemical (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylic acid is a type of pyrrole carboxylic acid. It is a chiral compound with a chiral center at the carbon atom attached to the phenylethyl group. The compound is used in the synthesis of various pharmaceuticals and biologically active compounds due to its unique structure and properties. It has been studied for its potential as an antifungal and antibacterial agent, as well as for its ability to modulate certain biological processes. The compound has also been investigated for its potential use in the development of new materials and as a building block for the synthesis of complex organic compounds.

InChI:InChI=1/C13H13NO2/c1-10(11-6-3-2-4-7-11)14-9-5-8-12(14)13(15)16/h2-10H,1H3,(H,15,16)/t10-/m1/s1

Upstream product

• 1100569-50-3 C₁₄H₁₅NO₂ 
• 13245-05-1 (S)-1-(1-phenylethyl)-1H-pyrrole 
• 571147-98-3 (S)-1-(1-phenylethyl)-2-trifluoroacetylpyrrole 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 407-25-0 trifluoroacetic anhydride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant articles and documents

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphology reminiscent of passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives. However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner.

New chiral rhodium(II) carboxylates and their use as catalysts in carbenoid transformations

New chiral dirhodium(II) carboxylates 11-15 have been prepared from the half phthalate esters 6-8 and the pyrroles 9 and 10, and their use as catalysts for the decomposition of diazocarbonyl compounds 16 and 18 investigated.