17400-34-9

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C11H16N2O2.ClH/c12-7-4-8-13-11(14)15-9-10-5-2-1-3-6-10;/h1-3,5-6H,4,7-9,12H2,(H,13,14);1H

Upstream product

• 134307-72-5 2-(((benzyloxy)carbonyl)amino)ethyl 1-methanesulfonate 
• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 177489-83-7 benzyl (3-azidopropyl)carbamate 
• 18807-68-6 N,N'-Dicarbobenzoxy-1,3-diaminopropan 
• 18877-96-8 3-<<(benzyloxy)carbonyl>amino>propionitrile 

Downstream Products

• 88106-01-8 2-<4-(4-hydroxyphenyl)butyryl>-L-1,2,3,4-tetrahydro-3-carboxyisoquinoline 3-(carbobenzoxyamino)propylamide 
• 88130-46-5 N-carbobenzoxy-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide 
• 86778-94-1 N-(4-phenylbutyryl)-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide 
• 88105-96-8 N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide 
• 88105-97-9 N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyltyrosine 3-(carbobenzoxyamino)propylamide 
• 86787-33-9 N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide 
• 88105-89-9 N-(4-phenylbutyryl)-L-prolyl-L-phenylalanine 3-(carbobenzoxyamino)propylamide 
• 89450-65-7 N-<2-(1-uracilyl)ethyl>-N'-carbobenzoxytrimethylenediamine hydrobromide 
• 89450-69-1 N-<3-(1-uracilyl)propyl>-N'-carbobenzoxytrimethylenediamine hydrobromide 
• 88105-58-2 N-carbobenzoxy-L-prolyl-L-phenylalanine 3-(carbobenzoxyamino)propylamide 
• 109-76-2 Trimethylenediamine 
• 319481-14-6 N-{5-O-[3-(Benzyloxycarbonylamino)propylcarbamoyl]-2,3-O-isopropylidene-β-D-ribofuranosyl}-3-(tert-butoxycarbonylamino)malonamide 
• 872315-98-5 {3-[(1S,2R)-2-[(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-1-(2,3-dihydro-indole-1-carbonyl)-2-hydroxy-ethylamino]-propyl}-carbamic acid benzyl ester 
• 872315-76-9 [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Yohimbine derivatives and use thereof

Yohimbine derivatives are disclosed having modification of the C-16 carboxyl group to include a sidechain and where the resulting derivative does not possess a second yohimbine pharmacophore (i.e., the compound is not a yohimbine dimer). The yohimbine derivatives of the present invention are preferably characterized by selective activity as α2c-AR antagonists. Use of the compounds, or pharmaceutical composition containing them, for treating or preventing an α2c adrenergic receptor mediated condition or disorder, and for antagonizing activity of an α2c adrenergic receptor are also disclosed.

An efficient and practical method for the synthesis of mono-N-protected α,ω-diaminoalkanes

The large-scale synthesis of mono-N-protected (Cbz, Boc, Ts, and Ns) α,ω-diaminoalkanes (the number of carbon atoms=3, 4, 5 and 6) are accomplished in 81-94% yield by the protection of amine and subsequent reduction of an azido group from α,ω-azido alkyl amines. α,ω-Azido alkyl amines are prepared efficiently by the partial reduction of α,ω-diazidoalkanes which are obtained from the corresponding dibromoalkanes.

SYNTHESIS OF N-(1-URACILYLALKYL)POLYMETHYLENEDIAMINES

The alkylation of polymethylenediamines with 2-(1-uracilyl)ethyl bromide and 3-(1-uracilyl)propyl bromide yields the corresponding N-(1-uracilylalkyl)polymethylendiamines.