17400-34-9Relevant articles and documents
Yohimbine derivatives and use thereof
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Page/Page column Sheet 1 of 9, (2009/01/24)
Yohimbine derivatives are disclosed having modification of the C-16 carboxyl group to include a sidechain and where the resulting derivative does not possess a second yohimbine pharmacophore (i.e., the compound is not a yohimbine dimer). The yohimbine derivatives of the present invention are preferably characterized by selective activity as α2c-AR antagonists. Use of the compounds, or pharmaceutical composition containing them, for treating or preventing an α2c adrenergic receptor mediated condition or disorder, and for antagonizing activity of an α2c adrenergic receptor are also disclosed.
SYNTHESIS OF 1,3-DIAMINES
Constantinou-Kokotou, Violetta,Kokotos, George
, p. 599 - 602 (2007/10/02)
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