174020-18-9Relevant academic research and scientific papers
Synergistic effect of 5-nitro-2'-deoxyuridine with ganciclovir against human cytomegalovirus in vitro
Rao,Rando,Huffman,Revankar
, p. 1997 - 2008 (1995)
In this paper we describe a practical synthesis of 5-nitro-2'- deoxyuridine (4) and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-nitrouracil (11). These compounds were then evaluated for their ability to inhibit the growth of human cytomegalovirus (HCMV, strain AD169) in MRC-5 cells using a plaque reduction assay. Compound 11 was unable to inhibit the growth of HCMV at the highest concentration tested (100 μg/mL). However, compound 4 (5- NO2-dU) exhibited marginal activity against HCMV in vitro in a dose- dependent manner with a 50% inhibitory concentrations (IC50) of 1 to 5 μg/mL. Combinations of 5-NO2-dU with ganciclovir synergistically inhibited HCMV induced cell killing in culture.
