174074-90-9

Basic information

• Product Name: 2-chloro-N-(4-chlorophenyl)quinazolin-4-amine
• Synonyms: 2-chloro-N-(4-chlorophenyl)quinazolin-4-amine
• CAS NO: 174074-90-9
• Molecular Weight: 290.152
• Mol File: 174074-90-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(4-chlorophenyl)quinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(4-chlorophenyl)quinazolin-4-amine(174074-90-9)
• EPA Substance Registry System: 2-chloro-N-(4-chlorophenyl)quinazolin-4-amine(174074-90-9)

Safety Data

• Hazardous Substances Data: 174074-90-9(Hazardous Substances Data)

Upstream product

• 607-68-1 2,4-dichloroquinazoline 
• 106-47-8 4-chloro-aniline 
• 134-20-3 2-carbomethoxyaniline 
• 2242-77-5 N-carbamoylanthranilic acid methyl ester 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 

Relevant articles and documents

JAK kinase inhibitor with 4-amino-(1H)-pyrazole structure and preparation method and application thereof

The invention discloses a JAK kinase inhibitor with 4-amino-(1H)-pyrazole structure and a preparation method and application thereof. The compound has a structure shown in general formula (I) or (II), and the invention provides a specific preparation meth

Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold

Abstract A series of compounds with quinazoline scaffold were designed, synthesized and evaluated as novel potent 5-HT2A receptor ligands. N-(4-Chlorophenyl)-2-(piperazin-1-yl)quinazolin-4-amine (5o) has a Ki value of 14.04 ± 0.21 nM, with a selectivity more than 10,000 fold over 5-HT1A receptors (D1 and D2-like receptors). The functional assay showed that this compound is an antagonist to 5-HT2A receptor with an IC50 value of 1.66 μM.