174087-91-3Relevant academic research and scientific papers
Synthesis of heterocyclic compounds from δ-unsaturated 1,3-diketo-esters
Albar, Hassan A.,Makki, Mohamad S. I.,Faidallah, Hassan M.
, p. 23 - 29 (2007/10/03)
Diketo-esters (1) have been synthesised and converted to the corresponding pyrazole (2), isoxazole (8) and 4-pyrone (10) derivatives. Fusion of 2 with hydrazine hydrate give the corresponding acid hydrazides (3). Reaction of 3 with the appropriate isothiocyanate yield the disubstituted thiosemicarbazides (4) which are cyclized into thiotriazoles (5), thiadiazoles (6) and oxadiazoles (7). Condensation of 3 with aromatic aldehydes yield the corresponding arylidenes (11) which are cyclized to dihydro-oxadiazole (12) and oxadiazole (13) derivatives. The Mannich bases (15) have also been prepared from the oxadiazole-2-thione (14).
