174088-65-4

Upstream product

• 174088-64-3 (2R,3R,4S,5S)-5-Benzyloxymethyl-2-methoxy-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-ol 
• 74-88-4 methyl iodide 
• 174088-63-2 (3aR,5S,6R,6aR)-5-Benzyloxymethyl-6-[2-(4-methoxy-phenoxy)-ethyl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 174088-62-1 {(3aR,5S,6R,6aR)-6-[2-(4-Methoxy-phenoxy)-ethyl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl}-methanol 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Synthesis of 2'-substituted sulfide-linked dinucleotides

3'-Deoxy-3'-(2-mesyloxyethyl)ribofuranosylthymine derivative 3, and its 2'-methoxy (16) and 2'-deoxy (38) analogs were condensed with 5'-deoxy-5'- thiothymidine 4 and 17 or 2'-O-methyl-5'-deoxy-5'-thiouridine 34 and 37 to provide, after standard functional group transformations, thymidine-thymidine and uridine-thymidine dimers 9, 21, 43 and 47. Oxidation of model sulfide dimer 48 with oxone gave sulfone 49. It was not stable to 27% ammonia.