17415-87-1Relevant academic research and scientific papers
A novel, one-step method for the conversion of primary alcohols into carbamate-protected amines
Wood, Michael R.,Kim, June Y.,Books, Kathy M.
, p. 3887 - 3890 (2007/10/03)
A novel process for the one-step conversion of primary alcohols into carbamate-protected amines has been developed using a modified Burgess reagent. Although this letter mainly focuses on the conversion of alcohols into the corresponding Cbz-protected amines, the potential for extending this process to a wide range of carbamates has also been demonstrated. A detailed catalytic cycle has been proposed. While exploring the scope of this new reagent, an N-aryl piperidine to an N-aryl pyrrolidine rearrangement has been observed and rationalized.
