883-44-3

Basic information

• Product Name: N-(3-HYDROXYPROPYL)PHTHALIMIDE
• Synonyms: 3-PHTHALIMIDO-1-PROPANOL;AURORA 4786;N-(3-HYDROXYPROPYL)PHTHALIMIDE;2-(3-Hydroxypropyl)-1H-isoindole-1,3(2H)-dione;2-(3-Hydroxypropyl)-2H-isoindole-1,3-dione;2-(3-Hydroxypropyl)isoindoline-1,3-dione;N-(3-Hydroxypropyl)phthalimide,99%;1H-Isoindole-1,3(2H)-dione, 2-(3-hydroxypropyl)-
• CAS NO: 883-44-3
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• EINECS: 212-931-1
• Product Categories: Carbonyl Compounds;Cyclic Imides;Organic Building Blocks
• Mol File: 883-44-3.mol
• Article Data: 36

Chemical Properties

• Melting Point: 74-76 °C(lit.)
• Boiling Point: 376.5ºC
• Flash Point: 181.5ºC
• Appearance: White/Crystalline Powder
• Density: 1.331 g/cm³
• Vapor Pressure: 2.44E-06mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.88±0.10(Predicted)
• BRN: 158489
• CAS DataBase Reference: N-(3-HYDROXYPROPYL)PHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-HYDROXYPROPYL)PHTHALIMIDE(883-44-3)
• EPA Substance Registry System: N-(3-HYDROXYPROPYL)PHTHALIMIDE(883-44-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 883-44-3(Hazardous Substances Data)

Usage

Description

N-(3-Hydroxypropyl)phthalimide, also known as ω-Hydroxyalkylphthalimide, is a white crystalline powder that is synthesized by mixing phthalic anhydride and propanolamine and heating at 160-180 °C for 4 hours. It serves as a standard in the synthesis of phthalimide derivatives under high-temperature, high-pressure, and H2O/EtOH mixtures as the solvent.

Uses

Used in Pharmaceutical Industry:
N-(3-Hydroxypropyl)phthalimide is used as a standard in the synthesis of phthalimide derivatives for the development of new pharmaceutical compounds. Its high-temperature, high-pressure, and H2O/EtOH mixtures as the solvent conditions allow for the production of these derivatives with improved properties and potential therapeutic applications.
Used in Polymer Synthesis:
N-(3-Hydroxypropyl)phthalimide is used in the synthesis of hydrophilic phosphorylcholine-containing polymers, such as poly-2-[3-(methacryloylamino)propylammonio]ethyl 3-aminopropyl phosphate. These polymers have potential applications in various fields, including drug delivery, tissue engineering, and biomaterials, due to their unique properties and biocompatibility.

InChI:InChI=1/C11H11NO3/c13-7-3-6-12-10(14)8-4-1-2-5-9(8)11(12)15/h1-2,4-5,13H,3,6-7H2

Upstream product

• 85-44-9 phthalic anhydride 
• 156-87-6 propan-1-ol-3-amine 
• 68276-73-3 3-((4-methylphenyl)sulfonyl)propan-1-ol 
• 1074-82-4 potassium phtalimide 
• 2058-49-3 3-(methylsulfonyl)propan-1-ol 
• 136918-14-4 phthalimide 
• 107-18-6 allyl alcohol 
• 2436-29-5 3-(N-phthaloyl)propionaldehyde 
• 5428-09-1 3-phthalimido-1-propene 
• 3485-84-5 N-vinylphthalimide 
• 201230-82-2 carbon monoxide 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 1402581-06-9 3-(4-methoxybenzyloxy)-1-phthalimidopropane 
• 627-32-7 1-iodopropan-3-ol 

Downstream Products

• 115306-79-1 3-(1,3-dioxoisoindolin-2-yl)propyl methanesulfonate 
• 2436-29-5 3-(N-phthaloyl)propionaldehyde 
• 88597-06-2 3-(phthalimido)propyl-p-toluenesulfonate 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 1197191-43-7 (S)-t-butyl 3-(4-(3-(1,3-dioxoisoindolin-2-yl)propoxy)-3-nitrophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate 
• 1402581-06-9 3-(4-methoxybenzyloxy)-1-phthalimidopropane 
• 476192-50-4 C₂₇H₃₁NO₈S 
• 150672-48-3 C₂₁H₁₈⁽²⁾H₂N₂O₅ 
• 150693-72-4 (Z)-2-Benzoylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pent-2-enoic acid methyl ester 
• 1026545-19-6 4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 388629-96-7 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-(2-phthalimidoethyl)isoquinoline 
• 388625-59-0 2-{2-[7-hydroxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione 
• 222022-30-2 2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione 

Relevant articles and documents

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Benzil compound as well as preparation method and application thereof

The invention provides a benzil compound as well as a preparation method and application thereof, the structure of the benzil compound is shown as a formula I, wherein R1 is -(CH2) n-N (CX1Y1Z1) (CX2Y2Z2), n is an integer from 1 to 6, and X1, X2, Y1, Y2, Z1 and Z2 are independently selected from hydrogen or deuterium. The benzil compound provided by the invention is applied to detection of guanidine compounds, can remarkably improve the sensitivity, accuracy and stability of detection, can be used for identifying potential guanidine compounds in a to-be-detected sample, and is low in cost.

Niraparib intermediate, preparation method and application thereof, and synthesis method of niraparib

The invention relates to a compound alpha-(3-aminopropyl)-p-bromophenylacetic acid, a preparation method and application thereof, (S)-3-(4-bromophenyl)-piperidine-2-one, a preparation method and application thereof, and synthesis methods of (S)-3-(4-bromophenyl)-piperidine) p-toluenesulfonate, N-Boc-(3S)-(4-bromophenyl)piperidine and niraparib. 4-bromophenylacetate 5 is used as a raw material, a nucleophilic reaction is carried out on the raw material and a nitrogen source reagent 4 under the action of an alkali to generate a compound 6; the compound 6 is subjected to deprotection and hydrolysis to obtain an amino acid compound 7; and the amino acid compound 7 is subjected to chiral column separation or chemical resolution to obtain compounds 8 and 9; and the separated enantiomer 8 can besubjected to racemization and resolution conversion (or chiral column separation) to obtain a compound 9, and the process material cost is greatly reduced. After the compound 9 is obtained, a compound1 can be obtained through conventional condensation reaction ring closing, reduction and BOC loading. Splitting operation is advanced, and the enantiomer 8 is subjected to racemization recovery treatment and is repeatedly applied to different splitting batches to continuously obtain the product 9, so the process material cost is lower.