174173-95-6

Upstream product

• 158800-64-7 (S)-4-((1R,3R)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2,2-dimethyl-[1,3]dioxolane 
• 128373-64-8 (2S,3E)-1,2-isopropylidene-5-O-benzyl-3-pentene-1,2,5-triol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 174173-94-5 (S)-1-((1R,3R)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol 

Downstream Products

• 201231-14-3 (1R,3R)-3-((R)-Benzyloxycarbonyl-tert-butoxycarbonylamino-methyl)-2,2-difluoro-cyclopropanecarboxylic acid benzyl ester 
• 201231-12-1 (R)-((1R,3R)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-tert-butoxycarbonylamino-acetic acid methyl ester 
• 201231-10-9 [(R)-1-((1R,3R)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 201231-08-5 (R)-2-Azido-2-((1R,3R)-3-benzyloxymethyl-2,2-difluoro-cyclopropyl)-ethanol 

Relevant academic research and scientific papers

Preparation of difluoro analogs of CCGs and their pharmacological evaluations

All the stereoisomers of 2-(2-carboxy-3,3-difluorocyclopropyl)glycines (F2CCGs) were synthesized in enantiomerically pure forms using (R)-2,3-O- isopropyl-ideneglyceraldehyde as a chiral precursor. L-F2CCG-I, one of the stereoisomers

A highly diastereoselective synthesis of trans-3,4-(difluoromethano)glutamic acid

Reaction of enantiomerically pure N-(4'-bromo-4',4'-difluorocrotonoyl)oxazolidinone 5 with lithium enolate of N-diphenylmethylideneglycinate 6 in DMF proceeded in highly diastereoselective manner to give trans-disubstituted gem-difluorocyclopropane 7, which was readily converted to the 3,4-(difluoromethano)glutamic acid 4.