174176-73-9Relevant academic research and scientific papers
A nanostructured label-free platform based on an ultrathin film for ultrasensitive detection of a secosteroid hormone
Raymundo-Pereira, Paulo A.,Lima, Alan R. F.,Machado, Sergio A. S.
, p. 34458 - 34467 (2016)
We report the electrocatalytic activity of perovskite-type LaNiO3-nanoxide (LN-NO) on secosteroid hormone oxidation in alkaline solution. LN-NO was synthesized by the Pechini method and calcined at 973 K for 2 h under air atmosphere. Subsequently, the LN-NO material was studied by high-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray (EDX), X-ray photoelectron spectroscopy (XPS), X-ray diffractometer (XRD) and electrochemical techniques such as cyclic voltammetry (CV), square wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). The Rietveld refinement by the XRD pattern indicated the presence only the LN-NO. Optimized electrocatalytic activity was achieved using the LN-NO architecture, on a label-free platform, and nanostructures with sizes ranging between 50 and 100 nm were well distributed throughout the nanoxide. The detection of the secosteroid was performed at a low potential (0.46 V vs. Ag/AgCl) in a range between 0 and 2.6 × 10-5 mol L-1, with a detection limit of 8.3 × 10-7 mol L-1, which is considerably competitive with similar devices. The application of the LN-NO nanostructured label-free platform as a voltammetric sensor showed a good sensitivity of 17.75 A M-1. Finally, the use of LN-NO as a low-cost alternative to carbon nanomaterials (nanotubes and graphene) has the potential to be an excellent approach to sensor development.
Synthesis and cytotoxic activity of steroid-anthraquinone hybrids
De Riccardis, Francesco,Izzo, Irene,Di Filippo, Marcello,Sodano, Guido,D'Acquisto, Fulvio,Carnuccio, Rosa
, p. 10871 - 10882 (1997)
Synthesis of cytotoxic steroidal derivatives containing a quinone moiety is described. The synthetic strategy is based on an unusual A + CD → ABCD Diels-Alder approach which generates 9β-H cholestane analogs. The adducts formed are efficiently aromatized
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
Deberardinis, Albert M.,Banerjee, Upasana,Miller, Michele,Lemieux, Steven,Hadden
scheme or table, p. 4859 - 4863 (2012/08/13)
A structure-activity relationship study to elucidate the structural basis for hedgehog (Hh) signaling inhibition by vitamin D3 (VD3) was performed. Functional and non-functional regions of VD3 and VD2 were obtained through straightforward synthetic means
