17422-98-9Relevant academic research and scientific papers
RhIII-catalyzed redox-neutral C-H activation of pyrazolones: An economical approach for the synthesis of N-substituted indoles
Fan, Zhoulong,Song, Shanshan,Li, Wei,Geng, Kaijun,Xu, Youjun,Miao, Ze-Hong,Zhang, Ao
, p. 310 - 313 (2015)
A new strategy is reported for the economical synthesis of indoles bearing an N-(3-aminobut-2-enoyl) substituent through RhIII-catalyzed redox-neutral C-H activation of pyrazolones and alkynes. This approach utilizes cheap substrates and mild reaction conditions to access a unique class of indoles via a N-N bond oxidative cleavage without loss of the N-terminus, therefore meeting all the atom/step/redox economy principles.
