174230-01-4Relevant academic research and scientific papers
A novel and general route to diverse A-ring aromatic trichothecanes via cyclobutanes
Nemoto, Hideo,Miyata, Junji,Fukumoto, Keiichiro
, p. 10363 - 10374 (2007/10/03)
A novel and generally applicable approach to A-ring aromatic trichothecane 2 was achieved by the regiocontrolled cyclization of 25, 26, 29, and 30 as a key step, followed by stereoselective construction of the epoxide ring. This manuscript also described the regiocontrolled ring expansion of the olefinic cyclobutanols 19-22 to give the enones 23 and 24 which were the important intermediates in this approach.
Cyclobutane strategy for the synthesis of a-ring aromatic trichothecanes
Nemoto, Hideo,Miyata, Junji,Fukumoto, Keiichiro
, p. 165 - 168 (2007/10/02)
A novel synthesis of A-ring aromatic trichothecane (2) by the regiocontrolled cyclization of 5-hydroxy-2-(2-methoxymethoxy-4-methylphenyl)-2-methyl-1-methylidenecyclopentane (10), which was prepared via the 2-phenyl-cyclobutanone (6) and cyclobutanols (7 and 8) and the 2-methylidene-3-phenylcyclopentanone (9), was achieved.
