6921-64-8

Basic information

• Product Name: 2'-Hydroxy-4'-methylacetophenone
• Synonyms: 1-(2-HYDROXY-4-METHYLPHENYL)ETHAN-1-ONE;1-(2-HYDROXY-4-METHYLPHENYL)ETHANONE;2'-HYDROXY-4'-METHYLACETOPHENONE;ASISCHEM D38758;1-(2-hydroxy-4-methylphenyl)-ethanon;4-Methyl-2-Hydroxyacetophenone;1-(2-HYDROXY-4-METHYLPHENYL)ETHAN-1-ON;Ethanone,1-(2-hydroxy-4-Methylphenyl)-
• CAS NO: 6921-64-8
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.17
• EINECS: 230-040-6
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;C9;Carbonyl Compounds;Ketones
• Mol File: 6921-64-8.mol
• Article Data: 49

Chemical Properties

• Melting Point: 21°C
• Boiling Point: 245 °C(lit.)
• Flash Point: >230 °F
• Appearance: black liquid
• Density: 1.08 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0177mmHg at 25°C
• Refractive Index: n20/D 1.565(lit.)
• Storage Temp.: 2-8°C
• PKA: 10.27±0.10(Predicted)
• CAS DataBase Reference: 2'-Hydroxy-4'-methylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Hydroxy-4'-methylacetophenone(6921-64-8)
• EPA Substance Registry System: 2'-Hydroxy-4'-methylacetophenone(6921-64-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 6921-64-8(Hazardous Substances Data)

Usage

Preparation

Preparation by treatment of methyl 4-hydroxy-7- methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (87%).

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 4183, 1996 DOI: 10.1016/0040-4039(96)00790-3

General Description

2′-Hydroxy-4′-methylacetophenone, also known as 1-(2-hydroxy-4-methylphenyl)ethanone can be synthesized by the Fries rearrangement of m-tolyl acetate in the presence of zirconium tetrachloride. The results from the toxicity studies on mite species suggest that 2′-hydroxy-4′-methylacetophenone possesses acaricidal property.

Upstream product

• 122-46-3 3-acetoxytoluene 
• 875-59-2 4'-hydroxy-2'methylacetophenone 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 72698-81-8 1-(4-acetoxy-2-methyl-phenyl)-ethanone 
• 64-19-7 acetic acid 
• 108-39-4 3-methyl-phenol 
• 75-36-5 acetyl chloride 
• 122-00-9 para-methylacetophenone 
• 7446-70-0 aluminium trichloride 
• 7664-39-3 hydrogen fluoride 
• 7550-45-0 titanium tetrachloride 
• 98-95-3 nitrobenzene 
• 107-06-2 1,2-dichloro-ethane 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 92725-97-8 1-[2-(2-diethylamino-ethoxy)-4-methyl-phenyl]-ethanone 
• 102005-37-8 1-[4-methyl-2-(2-morpholino-ethoxy)-phenyl]-ethanone 
• 1687-61-2 2-ethyl-5-methyl-phenol 
• 875-59-2 4'-hydroxy-2'methylacetophenone 
• 103440-91-1 1-(2-Hydroxy-4-methyl-5-nitrophenyl)ethanone 
• 114001-11-5 bis-(5-acetyl-4-hydroxy-2-methyl-phenyl)-sulfide 
• 114001-17-1 bis-(5-acetyl-4-hydroxy-2-methyl-phenyl)-sulfoxide 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 52923-28-1 (E)-1-(2-hydroxy-4-methylphenyl)-3-phenylprop-2-en-1-one 
• 58218-16-9 1-(2-hydroxy-4-methyl-phenyl)-butane-1,3-dione 
• 69301-57-1 2-(1-Hydroxy-1,5-dimethyl-hex-4-enyl)-5-methyl-phenol 
• 90609-65-7 2-Hydroxy-4-methyl-acetophenon-ketimin 
• 51379-11-4 Furan-2-carboxylic acid 2-acetyl-5-methyl-phenyl ester 
• 111391-45-8 (E)-3-(4-Benzyloxy-phenyl)-1-(2-hydroxy-4-methyl-phenyl)-propenone 

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