174265-02-2

Usage

Usage

Antimicrobial agent in personal care products (e.g. soaps, toothpaste, deodorants)

Structure

Phenol ring with a hydroxymethyl group and a trifluoromethyl group attached

Controversy

Potential negative impact on human health (e.g. hormone disruption) and the environment (e.g. development of antibiotic-resistant bacteria)

Restrictions

Limitations on use in certain products due to potential risks

Upstream product

• 7664-93-9 sulfuric acid 
• 79427-88-6 2-hydroxy-5-(trifluoromethyl)benzoic acid 
• 4864-01-1 2-methoxy-5-(trifluoromethyl)-benzoic acid 

Downstream Products

• 331729-55-6 [2-[(phenylmethyl)oxy]-5-(trifluoromethyl)phenyl]methanol 

Relevant academic research and scientific papers

AUTOTAXIN INHIBITORS COMPRISING A HETEROAROMATIC RING-BENZYL-AMIDE-CYCLE CORE

The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

PYRAZOLE AND TRIAZOLE CARBOXAMIDES AS CRAC CHANNEL INHIBITORS

The present invention relates to amide compounds of formula (I) processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing these compounds and to their use in therapy.

Azolyl methyl phenyl derivatives having aromatase inhibitory activity

Compounds exerting excellent aromatase inhibitory activity in vivo and in vitro with higher specificity and greater safety are provided together with the salts thereof. Using the same, there are also provided, prophylactic agents and/or therapeutical agents of estrogen-dependent diseases, contraceptive agents for females, and aromatase inhibitory agents for use in the form of reagents for human or animals. The compounds are of the formula (I), wherein R2 is represented by the formula (II) or (III). (I) (II) or