174272-02-7Relevant articles and documents
High performance polymer supports for enzyme-assisted synthesis of glycoconjugates
Yamada, Kuriko,Fujita, Eriko,Nishimura, Shin-Ichiro
, p. 443 - 461 (2007/10/03)
Efficient and practical methodology for the construction of carbohydrates, including oligosaccharide derivatives and sphingoglycolipids, was established on the basis of a watersoluble polymer supports having unique linkers that can be cleaved by specific
An Efficient Synthesis of Sialoglycoconjugates on a Peptidase-Sensitive Polymer Support
Yamada, Kuriko,Nishimura, Shin-Ichiro
, p. 9493 - 9496 (2007/10/02)
A novel method for the enzymatic synthesis of oligosaccharide derivatives on a α-chymotrypsin-sensitive polymer support is described.The primer polymer having N-acetyl-D-glucosamine (GlcNAc) residue through a phenylalanine-containing spacer moiety was successfully elongated with galactosyl and sialyltransferases to give a glycopolymer bearing sialyl α(2->) N-acetyllactosamine branches in high yield.Subsequent hydrolysis with α-chymotripsin proceeded smoothly and afforded a versatile sialotrisaccharide derivative having a terminal amino group which can be used for creating neoglycoconjugates.