174272-63-0

Upstream product

• 1326317-13-8 methyl 2-(tert-butoxycarbonylamino)-3-(2,5-dimethoxyphenyl)propanoate 
• 1360441-82-2 methyl 2-(benzyloxycarbonylamino)-3-(2,5-dimethoxyphenyl)acrylate 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 1326317-11-6 methyl 2-(tert-butoxycarbonylamino)-3-(2,5-dimethoxyphenyl)acrylate 

Downstream Products

• 1326317-16-1 methyl 2-(2-(2,5-dimethoxy phenyl) acetyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1326317-20-7 methyl 2-(4-(2,5-dimethoxyphenyl)butanoyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1326317-22-9 2-(2-(2,5-dihydroxyphenyl)acetyl)-5,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 1326317-26-3 2-(4-(2,5-dihydroxyphenyl)butanoyl)-5,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 1326317-18-3 methyl 2-(3-(2,5-dimethoxyphenyl)propanoyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1326317-24-1 2-(3-(2,5-dihydroxyphenyl)propanoyl)-5,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 198021-01-1 ethyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Relevant academic research and scientific papers

Electronically rich N-substituted tetrahydroisoquinoline 3-carboxylic acid esters: Concise synthesis and conformational studies

Recent work in our laboratory has shown that the highly substituted, electronically rich 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQ3CA) scaffold is a key building block for a novel class of promising anticoagulants.10 The synthesis

Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa

Antithrombin is a key regulator of coagulation and prime target of heparins, clinically used anticoagulants. Heparins induce a two-step conformational activation of antithrombin, a process that has remained challenging to target with molecules devoid of t