17428-64-7

Upstream product

• 17702-41-9 nido-decaborane 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 16390-61-7 1-phenyl-1,2-closo-C₂B₁₀H₁₁ 
• 636-98-6 p-nitrobenzene iodide 
• 16872-09-6 1,2-dicarba-closo-dodecaborane⁽¹²⁾ 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 7697-37-2 nitric acid 

Downstream Products

• 23738-81-0 1-(4-aminophenyl)-2-dicarbodecaborane 

Relevant academic research and scientific papers

Thermal curing of novel carborane-containing phenylethynyl terminated imide oligomers

A novel carborane-containing phenylethynyl terminated imide compound (Carb-PEPA) as a modifier for fluorinated phenylethynyl terminated imide oligomer (AFR-PEPA) was synthesized and characterized by FT-IR and 1H-NMR. The resin systems consisting of Carb-PEPA and AFR-PEPA (AFR-PEPA-Carb) were prepared with different weight fractions of Carb-PEPA. The thermal curing kinetics and thermal stability of the imide compound and resultant resin systems were analyzed by using DSC and TGA respectively. The relevant kinetic data were determined by a Kissinger method. The results show that the glass transition temperatures (Tg) of the cured resin systems increase with the addition of Carb-PEPA. The imide system containing 20 wt% Carb-PEPA (AFR-PEPA-Carb-20) exhibits the highest Tg of 389.5 °C due to the high steric hindrance of carborane. The char yield of the resin was also increased with the introduction of the carborane structure in the system. The kinetic data indicate that AFR-PEPA/Carb-PEPA imide blends have higher activation energy E and frequency factor A than AFR-PEPA imide oligomers.

Tumour-targetted Boranes. Part 3. Synthesis of Carbamate-linked Nitroimidazolyl Carboranes Designed for Boron Neutron Capture Therapy of Cancer

Carboranes targetted to specific tumour tissues are important for boron neutron capture therapy of cancer (BNCT).Carbamoylation of 2-ethoxy>ethanol 5 and 1-(chloromethyl-2-(nitroimidazol-1-yl)ethanol 6 with carboran-1-yl isocyanate (generated in situ by a Curtius rearrangement of carborane-1-carbonyl azide) gave the corresponding carbamate-linked nitroimidazolylcarboranes 16 and 17.A similar reaction of 4-carboranylphenyl isocyanate with 6 afforded the corresponding carbamate 24.

C-arylation and C-heteroarylation of icosahedral carboranes via their copper(I) derivatives

Reaction between C-mono- or C,C'-di-copper(I) derivatives of 1,2- 1,7-, or 1,12-dicarba-closo-dodecaborane(12) and aryl iodides in the presence of pyridine gives the corresponding C-mono- or C,C'-diaryl derivatives of 1,7- and 1,12-dicarba-closo-dodecaboranes(12); 1,2-dicarba-closo-dodecaborane(12) gives only the C-monoaryl product.Cyclic or linear arylene coupled systems are obtained when di-iodoarenes are used.Copper(I) derivatives may be generated from C-unsubstituted or C-monosubstituted carboranes using copper(I) t-butoxide when substituents incompatible with the use of C-lithio-intermediates are involved.The C-copper(I) derivative of 1,2-dicarba-closo-dodecaborane(12) gives 1,2-di-2'-pyridyl-1,2-dicarba-closo-dodecaborane(12) specifically with 2-bromopyridine.The (inferred) intermediate mono-2-pyridyl-derivative, obtained independently from 2-ethynylpyridine and the dimethylsulphide complex of decaborane, gives 1-phenyl-2,2'-pyridyl-1,2-dicarba-closo-dodecaborane(12) upon conversion into its copper(I) derivative and treatment with iododobenzene.However, the copper(I) derivative of 1-phenyl-1,2-dicarba-closo-dodecaborane(12) does not react to a significant extent with 2-bromopyridine.