23738-81-0

Basic information

• Product Name: 1-(4-aminophenyl)-2-dicarbodecaborane
• Synonyms: 1-(4-aminophenyl)-2-dicarbodecaborane
• CAS NO: 23738-81-0
• Molecular Weight: 235.34
• Mol File: 23738-81-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-aminophenyl)-2-dicarbodecaborane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-aminophenyl)-2-dicarbodecaborane(23738-81-0)
• EPA Substance Registry System: 1-(4-aminophenyl)-2-dicarbodecaborane(23738-81-0)

Safety Data

• Hazardous Substances Data: 23738-81-0(Hazardous Substances Data)

Upstream product

• 17428-64-7 1-(4-nitrophenyl)-2-dicarbodecaborane 

Downstream Products

• 12091-00-8 1-C₆H₄-4'-N(CH₂CH₂OH)2-1.2-C₂B₁₀H₁₁ 
• 96055-92-4 1-(p-isothiocyanatophenyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾ 
• 91997-72-7 tetramethylammonium 7-(p-aminophenyl)dodecahydro-7,8-dicarba-nido-undecaborate^(1-) 
• 158565-51-6 4-(1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl)phenyl isocyanate 
• 23810-15-3 1-C₆H₄-4'-NHCOCH₃-1.2-C₂B₁₀H₁₁ 

Relevant articles and documents

Histone Deacetylase 2 (HDAC2) Inhibitors Containing Boron

Histone deacetylase enzymes (HDACs) are responsible for the global silencing of tumour-suppressor genes. Treatment with a histone deacetylase inhibitor (HDACi) can reverse this process and restore normal cell function. Herein, we report a small series of boron-based (boronic acid, boronate ester and closo-1,2-carborane) HDAC2 inhibitors with IC50 values in the nanomolar range. The boronate ester 4 b was the most potent compound assessed in this study (IC50=40.6±1.5 nM), followed closely by the 1,2-closo-carborane (IC50=42.9±1.5 nM). Compound 4 b exceeds the potency of the related gold-standard HDAC pan-inhibitor vorinostat (1) toward this particular HDAC isoform.

Tumour-targetted Boranes. Part 3. Synthesis of Carbamate-linked Nitroimidazolyl Carboranes Designed for Boron Neutron Capture Therapy of Cancer

Carboranes targetted to specific tumour tissues are important for boron neutron capture therapy of cancer (BNCT).Carbamoylation of 2-ethoxy>ethanol 5 and 1-(chloromethyl-2-(nitroimidazol-1-yl)ethanol 6 with carboran-1-yl isocyanate (generated in situ by a Curtius rearrangement of carborane-1-carbonyl azide) gave the corresponding carbamate-linked nitroimidazolylcarboranes 16 and 17.A similar reaction of 4-carboranylphenyl isocyanate with 6 afforded the corresponding carbamate 24.