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1743-86-8

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1743-86-8 Usage

Description

2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE is a specialized chemical compound that incorporates elements like carbon, hydrogen, nitrogen, sulfur, and fluorine. Notable for its aromatic phenyl group and the presence of a trifluoromethyl group and an isothiocyanate group, which significantly influences its chemical behavior and properties. It is usually used as a specialty chemical for research purposes and is utilized in organic synthesis. Exact properties like its boiling point, melting point, and exact toxicity levels may vary significantly. Details about its physical state, color, solubility, and stability can also be defined by specific conditions. As it's a complex chemical compound, handling it requires specific caution to avoid potential hazards or health risks.

Uses

Used in Research Applications:
2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE is used as a specialty chemical for research purposes, particularly in the field of organic synthesis. Its unique structure and properties make it a valuable compound for studying chemical reactions and developing new synthetic pathways.
Used in Organic Synthesis:
In the field of organic chemistry, 2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE is used as a key intermediate or reagent in the synthesis of various complex molecules. Its presence of a trifluoromethyl group and an isothiocyanate group allows for a wide range of reactions, making it a versatile building block for the creation of new compounds.
Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique chemical properties can be exploited to develop new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical structure can be modified to create new active ingredients with improved efficacy and selectivity.
Used in Material Science:
2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE is used in the development of new materials with specific properties, such as high thermal stability, chemical resistance, or unique optical characteristics. Its incorporation into polymers or other materials can lead to the creation of advanced materials for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1743-86-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,4 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1743-86:
(6*1)+(5*7)+(4*4)+(3*3)+(2*8)+(1*6)=88
88 % 10 = 8
So 1743-86-8 is a valid CAS Registry Number.
InChI:1S/C8H4F3NS/c9-8(10,11)6-3-1-2-4-7(6)12-5-13/h1-4H

1743-86-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L10586)  2-(Trifluoromethyl)phenyl isothiocyanate, 98%   

  • 1743-86-8

  • 1g

  • 278.0CNY

  • Detail
  • Alfa Aesar

  • (L10586)  2-(Trifluoromethyl)phenyl isothiocyanate, 98%   

  • 1743-86-8

  • 5g

  • 1079.0CNY

  • Detail
  • Aldrich

  • (474827)  2-(Trifluoromethyl)phenylisothiocyanate  98%

  • 1743-86-8

  • 474827-5G

  • 1,206.27CNY

  • Detail

1743-86-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE

1.2 Other means of identification

Product number -
Other names Isothiocyanic Acid 2-(Trifluoromethyl)phenyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1743-86-8 SDS

1743-86-8Relevant articles and documents

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

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Page/Page column 93; 108-109, (2020/11/03)

Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

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Page/Page column 84; 98; 99, (2019/05/15)

Compounds of formula (I) processes for their production and their use as pharmaceuticals.

Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis

G?tz, Kathrin H.,Hacker, Stephan M.,Mayer, Daniel,Dürig, Jan-Niklas,Stenger, Steffen,Marx, Andreas

, p. 2682 - 2689 (2017/10/27)

The intracellular concentration of diadenosine tetraphospate (Ap4A) increases upon exposure to stress conditions. Despite being discovered over 50 years ago, the cellular functions of Ap4A are still enigmatic. If and how the varied Ap4A is a signal and involved in the signaling pathways leading to an appropriate cellular response remain to be discovered. Because the turnover of Ap4A by Ap4A cleaving enzymes is rapid, small molecule inhibitors for these enzymes would provide tools for the more detailed study of the role of Ap4A. Here, we describe the development of a high-throughput screening assay based on a fluorogenic Ap4A substrate for the identification and optimization of small molecule inhibitors for Ap4A cleaving enzymes. As proof-of-concept we screened a library of over 42, 000 compounds toward their inhibitory activity against the Ap4A phosphorylase (Rv2613c) of Mycobacterium tuberculosis (Mtb). A sulfanylacrylonitril derivative with an IC50 of 260 ± 50 nM in vitro was identified. Multiple derivatives were synthesized to further optimize their properties with respect to their in vitro IC50 values and their cytotoxicity against human cells (HeLa). In addition, we selected two hits to study their antimycobacterial activity against virulent Mtb to show that they might be candidates for further development of antimycobacterial agents against multidrug-resistant Mtb.

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