1743-96-0

Usage

Uses

Used in Pharmaceutical Synthesis:
Benzene, 1-nitro-4-(pentafluoroethoxy)is utilized as a key intermediate in the production of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with specific therapeutic properties, contributing to the development of novel treatments for a range of medical conditions.
Used in Pesticide Production:
Benzene, 1-nitro-4-(pentafluoroethoxy)also serves as an essential intermediate in the synthesis of pesticides, where its chemical properties can be leveraged to enhance the effectiveness of these agricultural chemicals. Its use in this industry helps to improve crop protection and contribute to increased agricultural productivity.
Used in Organic Compound Synthesis:
Benzene, 1-nitro-4-(pentafluoroethoxy)is employed in the synthesis of a variety of organic compounds, showcasing its versatility in organic chemistry. Its unique functional groups enable the formation of diverse chemical products, which can be applied across multiple industries, including materials science, fragrances, and dyes.
Used in Chemical Research:
Due to its distinctive structure and properties, Benzene, 1-nitro-4-(pentafluoroethoxy)is also used in chemical research to explore new reaction pathways, investigate the effects of fluorination on chemical behavior, and develop new synthetic methodologies. This research can lead to advancements in the field of chemistry and the discovery of innovative applications for Benzene, 1-nitro-4-(pentafluoroethoxy)-.

Upstream product

• 100-02-7 4-nitro-phenol 
• 658-78-6 1-nitro-4-trifluoroacetoxy-benzene 

Downstream Products

• 98-16-8 3-trifluoromethylaniline 

Relevant academic research and scientific papers

2-Trifluoromethyl-1,3-dithianylium triflate: A convenient 'masked' electrophilic pentafluoroethylation reagent

With 2-trifluoromethyl-1,3-dithianylium triflate for the first time the synthesis, isolation and full structural characterization of an α-perfluoroalkylcarbenium salt was achieved. The title compound can be easily obtained on a preparative scale. The thermally stable dithianylium salt in combination with fluorodesulfurization chemistry is a promising novel reagent for the electrophilic polyfluoroalkylation of organic substrates, demonstrated by the pentafluoroethylation of O-nucleophiles.

Fluorination process

It has been found that a compound of formula (I) R-CF2-O-Ar, wherein R is a fluorinated alkyl group or an optionally substituted aromatic or heteroaromatic group and Ar is an optionally substituted aromatic or heteroaromatic group, can be produced by a process comprising a step of reacting a compound of formula (II) R-C(O)-O-Ar wherein R and Ar are as defined above with a fluorination agent at a temperature of below +100°C.

FLUORINATION PROCESS

It has been found that a compound of formula (I) R-CF2-O-Ar, wherein R is a fluorinated alkyl group or an optionally substituted aromatic or heteroaromatic group and Ar is an optionally substituted aromatic or heteroaromatic group, can be produced by a process comprising a step of reacting a compound of formula (II) R-C(O)-O-Ar wherein R and Ar are as defined above with a fluorination agent at a temperature of below +100°C.

Process for preparing compounds containing a difluoromethylene group in a position α to an oxygen atom

A process for the preparation of compounds containing a difluoromethylene group in a position α to an oxygen atom. An alcohol or a phenol is brought into contact with trifluoroacetic acid or a halide or anhydride thereof in anhydrous liquid hydrofluoric acid, in the presence of boron trifluoride, in a quantity such that the absolute pressure of boron trifluoride is at least about one bar. The compounds obtained according to the invention are used as synthesis intermediates in the pharmaceutical, plant-protection, and dye industries, as anesthetics and as additives for lubricating oils.