174311-81-0Relevant articles and documents
Mild and adaptable silver triflate-assisted method for trityl protection of alcohols in solution with solid-phase loading applications
Lundquist IV, Joseph T.,Satterfield, Andrew D.,Pelletier, Jeffrey C.
, p. 3915 - 3918 (2007/10/03)
Trityl ethers were prepared in solution in a matter of minutes by treating trityl chloride with silver triflate in the presence of alcohols. Yields were comparable or better than known literature methods. The method was compatible with the base-labile Fmo
Method for preparing alkylating agents and their use for alkylating cyclic ureas
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, (2008/06/13)
This invention relates to methods for preparing alkylating agents and use of the agents prepared. In particular, this invention relates to preparation methods for hydroxy halide and organooxy halide alkylating agents and their use for alkylating cyclic urea compounds.
Stereoselective synthesis of HIV-1 protease inhibitor, DMP 323
Pierce,Pierce, Michael E.,Harris,Harris, Gregory D.,Islam,Islam, Qamrul,Radesca,Radesca, Lilian A.,Storace,Storace, Louis,Waltermire,Waltermire, Robert E.,Wat,Wat, Ed,Jadhav,Jadhav, Prabhakar K.,Emmett,Emmett, George C.
, p. 444 - 450 (2007/10/02)
DMP 323, a potent HIV-1 protease inhibitor, has been synthesized by an efficient stereoselective process, amenable to large scale preparations. The core C2 symmetric diol was synthesized by a stereoselective pinacol coupling of CBZ protected D-phenylalanine. Judicious selection of protecting groups allowed cyclic urea formation under mild conditions, enhanced the ease of bis-alkylation, and led te intermediates which were easily purified without chromatography. Additionally, a one-pot, high yield process was developed te prepare the alkylating agent, 4-[(triphenylmethoxy)methyl]benzyl chloride from 1,4-benzenedimethanol.