174339-93-6Relevant academic research and scientific papers
5-HT6 serotonin receptor binding affinities of N1-benzenesulfonyl and related tryptamines
Lee,Rangisetty,Dukat,Slassi,Maclean,Lee,Glennon
, p. 230 - 242 (2007/10/03)
N1-Benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine (BS/5-OMe DMT, 2; Ki = 2.1 nM) binds at 5-HT6 receptors with enhanced affinity relative to 5-OMe DMT (Ki = 77 nM). The role of the benzenesulfonyl group was examined by replacing th
5-HT-1D receptor ligands
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, (2008/06/13)
Described herein are tryptamine analogs that display high binding affinity and selectivity for the 5-HT1Dβ receptor, of the formula: STR1 wherein R 1 is a group selected from aryl-C 1-7 alkyl; aryl-C 2-7 alkoxy; aryl-C 2-7 alkanoyl and aryl-C 1-7 alkanoyloxy, wherein said alkyl, alkoxy, alkanoyl and alkanoyloxy groups are optionally substituted by a C 1-4 alkyl substituent and wherein said aryl group is optionally substituted by one or more substituent selected from hydroxyl, halogen, mercapto, linear or branched C 1-4 alkyl, linear or branched C 1-4 alkoxy, linear or branched C 1-4 alkylthio, thiol substituted C 1-4 alkyl and nitro substituted C 1-4 alkyl;R 2 and R 3 are selected independently from H and C 1-4 alkyl; andR 4 is selected from H, C 1-4 alkyl, aryl and arylC 1-4 alkyl. The compounds are useful as reagents for receptor identification and in receptor-based drug screening programs, and can also be used therapeutically to treat conditions for which administration of a 5-HT1D ligand is indicated, for example in the treatment of migraine.
Binding of 5-Arylalkyloxytryptamines at Human 5-HT1Dβ Serotonin Receptors
Hong, Seoung-Soo,Dukat, Malgorzata,Teitler, Milt,Herrick-Davis, Kathy,McCallum, Kirk,et al.
, p. 690 - 699 (2007/10/03)
Several 5-substituted tryptamine derivatives were prepared and examined for their binding at 5-HT1D serotonin receptors. Initially, a region of bulk tolerance was probed. Subsequently, a series of 5-(arylalkyloxy)tryptamines was prepared. Within a homolog
