15733-63-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Chloro-5-phenylpentane is used as an intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the formation of new compounds through organic synthesis reactions.
Used in Agrochemical Industry:
1-Chloro-5-phenylpentane is used as a precursor in the production of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
1-Chloro-5-phenylpentane is utilized as a reactant in organic synthesis processes, enabling the creation of a wide range of chemical compounds for various applications across different industries.

InChI:InChI=1/C11H15Cl/c12-10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2

Upstream product

• 10521-91-2 5-phenylpentan-1-ol 
• 628-76-2 1,5-dichloropentane 
• 71-43-2 benzene 
• 2270-20-4 5-Phenylpentanoic acid 
• 1745-16-0 5-phenylpent-2-ene 
• 24463-87-4 (5-chloropent-1-ynyl)benzene 
• 28557-00-8 phenylzinc chloride 
• 4224-70-8 6-bromohexanoic acid 
• 1462-75-5 3-phenylpropylmagnesium bromide 

Downstream Products

• 75553-28-5 Essigsaeure-(5-phenylpentyl)ester 
• 101747-20-0 (5-phenoxypentyl)benzene 
• 538-68-1 pentylbenzene 
• 35511-93-4 1,10-diphenyldecane 
• 700-88-9 cyclopentylbenzene 
• 1718-50-9 1,5-diphenylpentane 
• 99858-37-4 5-iodopentylbenzene 
• 105907-38-8 1-(5-chloro-pentyl)-4-nitro-benzene 
• 7508-26-1 (5-phenyl-pentyl)-malonic acid 
• 178980-17-1 5-(3,5-dichlorophenylthio)-2-hydroxymethyl-4-isopropyl-1-(5-phenylpentyl)-1H-imidazole 
• 77975-48-5 4-(5-phenylpentylthio)-1-β-D-ribofuranosyl-pyrazolo[3,4-d]pyrimidine 
• 61439-74-5 ethyl p-[(5-phenylpentyl)amino]benzoate 
• 61439-75-6 p-[(5-Phenylpentyl)amino]benzoic Acid 
• 54636-25-8 3,8-Diphenyl-2-octanon 

Relevant academic research and scientific papers

Catalytic remote hydrohalogenation of internal alkenes

Primary alkyl halides have broad utility as fine chemicals in organic synthesis. The direct halogenation of alkenes is one of the most efficient approaches for the synthesis of these halides. Internal alkenes, in particular mixtures of isomers from refine

Synthesis of N-ω-phenylalkyl-4-(p-chlorophenyl)-piperidin-4-ol analogues with potent antiproliferative activity against HCT-116 cells

Some opioid analogues, such as morphine and loperamide, were reported to exhibit weak antiproliferative activity against tumor cells. In a study of loperamide analogues, we found that adding an N-ω-phenylalkyl group onto the 4-arylpiperidin-4-ol unit can have important effects on the antiproliferative activity of such compounds against HCT-116 cells. We optimized the distance between the phenyl group and 4-arylpiperidin unit to promote such activity.

Catalytic Chemoselective and Stereoselective Semihydrogenation of Alkynes to E-Alkenes Using the Combination of Pd Catalyst and ZnI2

An efficient E-selective semihydrogenation of internal alkynes was developed under low dihydrogen pressure and low reaction temperature from commercially available reagents: Cl2Pd(PPh3)2, Zn0, and ZnI2. Kinetic studies and control experiments underline the significant role of ZnI2 in this process under H2 atmosphere, establishing that the transformation involves syn-hydrogenation followed by isomerization. This simple and easy-to-handle system provides a route to E-alkenes under mild conditions.

Redox-Active Esters in Fe-Catalyzed C-C Coupling

Cross-couplings of alkyl halides and organometallic species based on single electron transfer using Ni and Fe catalyst systems have been studied extensively, and separately, for decades. Here we demonstrate the first couplings of redox-active esters (both isolated and derived in situ from carboxylic acids) with organozinc and organomagnesium species using an Fe-based catalyst system originally developed for alkyl halides. This work is placed in context by showing a direct comparison with a Ni catalyst for >40 examples spanning a range of primary, secondary, and tertiary substrates. This new C-C coupling is scalable and sustainable, and it exhibits a number of clear advantages in several cases over its Ni-based counterpart.

Trichloroisocynuric acid/DMF as efficient reagent for chlorodehydration of alcohols under conventional and ultrasonic conditions

A new and efficient method for the chlorodehydration of alcohols utilizing TCCA/DMF is described. Various alcohols can be converted smoothly into their corresponding alkyl chlorides in high yields under mild conditions with short reaction times. Taylor & Francis Group, LLC.

Halogenation of primary alcohols using a tetraethylammonium halide/[Et 2NSF2]BF4 combination

The halogenation of primary alcohols is presented. The use of a combination of tetraethylammonium halide and [Et2NSF2]BF4 (XtalFluor-E) allows for chlorination and bromination reactions to proceed efficiently (up to 92% yield) with a wide range of alcohols. Iodination reactions are also possible albeit in lower yields.

Preparation of ternary platinum(II) complexes with N-(ω-phenylalkyl)- 1,2-ethanediamine and 2,2′-dipyridine and the effect of the methylene chain length of the N-(ω-phenylalkyl)-1,2-ethanediamine in the complexes on intermolecular interactions with various arylsulfonates

A series of ternary complexes comprised of platinum(II), 2,2′-dipyridine, and N-(ω-phenylalkyl)-1,2-ethanediamine was prepared by varying the number (n) of methylene chain carbons between the phenyl group and one of the amino groups of 1,2-ethanediamine. NMR measurements indicated that intramolecular stacking occurred for n=1 and intermolecular stacking occurred for n=3 for several of the aryl sulfonates.