174355-32-9Relevant academic research and scientific papers
Predicting the diastereoselectivity of Rh-mediated intramolecular C-H insertion
Taber, Douglass F.,You, Kamfia K.,Rheingold, Arnold L.
, p. 547 - 556 (2007/10/03)
Rhodium-mediated cyclization of the α-diazo ester 1 proceeds with high diastereoselectivity, to give the trisubstituted cyclopentane 5. A computational model (ZINDO and Molecular Mechanics) based on our current mechanistic understanding of the reaction is presented. This model correctly predicts the dominant diastereomer from the cyclization of 1 and the eight (Table 2) other α-diazo esters studied thus far.
