174358-69-1

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 121-33-5 vanillin 
• 176375-41-0 4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester 

Downstream Products

• 174358-70-4 4-(4-Formyl-2-methoxy-5-nitro-phenoxy)-butyric acid 2-trimethylsilanyl-ethyl ester 
• 174358-67-9 4-{4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxycarbonyloxymethyl]-2-methoxy-5-nitro-phenoxy}-butyric acid 2-trimethylsilanyl-ethyl ester 
• 174358-72-6 4-{4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxycarbonyloxymethyl]-2-methoxy-5-nitro-phenoxy}-butyric acid 
• 174358-71-5 4-(4-Hydroxymethyl-2-methoxy-5-nitro-phenoxy)-butyric acid 2-trimethylsilanyl-ethyl ester 
• 263758-69-6 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid 

Relevant academic research and scientific papers

Simply methoxy curcumin water-soluble derivative and its preparation and use

The invention provides a water-soluble monodemethoxycurcumin derivative as shown in general formula I and a pharmaceutically acceptable salt thereof. The compound has higher water solubility as well as high antitumor activity, has a function of inhibiting human gastric carcinoma cells MGC-803, human hepatocellular carcinoma cells Bel-7402, human chronic leukemia granulocytes K562 and human glioma U87 to different extents, and can be used for preparing an antitumor medicament, and the IC50 (Inhibitory Concentration 50) reaches the level of 1 [mu]M.

Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

Improved utility of photolabile solid phase synthesis supports for the synthesis of oligonucleotides containing 3'-hydroxyl termini

Oligonucleotides are synthesized on, and cleaved from, a solid phase support (6) using the o-nitrobenzyl intramolecular photochemical redox reaction. The yields of isolated oligonucleotides relative to yields obtained using conventional hydrolytic cleavage vary between 67% and 82.5%. Synthesis of oligonucleotides using phosphoramidites that do not contain N-benzoyl protecting groups enables one to photolytically cleave the biopolymers in good yields using a commonly available UV irradiation source. Tritium labeling indicates that less than 3% thymidine·thymidine photodimers are formed during photolytic cleavage of polythymidylates from 6 using a transilluminator. No UV-induced damage is detected via HPLC analysis of enzymatically digested oligonucleotides that were obtained following photolytic cleavage from 6.