174362-09-5Relevant articles and documents
New synthetic routes to Z-shape functionalized perylenes
Bhargava Rao, Billa,Wei, Jun-Ru,Lin, Chih-Hsiu
, p. 3640 - 3643 (2012)
Z-shape (1,2,7,8-tetrasubstituted) perylene derivatives are novel chromophores with great potential in various applications. Yet, the synthetic entry into this class of molecules is hitherto quite limited. In this communication, the synthesis of a series
BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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Paragraph 0134; 0135, (2019/03/29)
Disclosed are a benzazepine derivative, a preparation method, a pharmaceutical composition and the use thereof. A compound as shown in formula (I) of the present invention, and an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure. The benzazepine derivative of the present invention has a good regulation effect on the TLR family and the related signalling pathway, and in particular, has a good regulation effect on TLR8, can effectively treat, relieve and/or prevent various diseases mediated by TLR family and the TLR-related signalling pathway, and in particular, can effectively treat, relieve and/or prevent various diseases mediated by TLR8, such as cancers, autoimmune diseases, infections, inflammations, transplantation rejections, graft-versus-host diseases, etc.
Engaging Allene-Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]-Annulation Reaction
Sankar, Muthukumar G.,Garcia-Castro, Miguel,Golz, Christopher,Strohmann, Carsten,Kumar, Kamal
supporting information, p. 9709 - 9713 (2016/08/10)
Catalytic addition of chiral phosphine, that is, (R)- or (S)-SITCP, to an α-substituted allene ester generated a zwitterionic dipole. Under optimized reaction conditions, this dipole could engage isatine-derived N-Boc-ketimines in a novel mode of [3+2] an
METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES
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Page/Page column 26-28, (2010/06/11)
The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.
Synthesis of β-enaminoesters and lactams by Michael addition of N- benzylaniline to new allenic esters and lactams
Ibrahim-Ouali, Malika,Sinibaldi, Marie-Eve,Troin, Yves,Gardette, Daniel,Gramain, Jean-Claude
, p. 1827 - 1848 (2007/10/03)
The synthesis of original allenic lactams 2 and allenic esters 5 is presented and their Michael condensation with N-benzylaniline described.