17437-24-0

Upstream product

• 820-41-7 ω-Amino-7-oxo-stearinsaeure 
• 247063-08-7 18-(dibenzylamino)-12-octadecenoic acid 
• 2380-16-7 methyl 18-hydroxyoctadecanoate 
• 871-70-5 octadecanedioic acid 
• 1472-93-1 dimethyl 1,18-octadecanedioate 
• 72849-35-5 1,18-octadecanedioic acid monomethyl ester 
• 16595-66-7 2-(syn-2-Oxo-cyclohexyliden)-1-aza-cyclotridecan 

Relevant academic research and scientific papers

Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells

Lactosylceramide [LacCer; β-Gal-(1-4)-β-Glc-(1-1)-Cer] has been shown to contain very long fatty acids that specifically modulate neutrophil properties. The interactions between LacCer and proteins and their role in cell signaling processes were assessed

PROTEIN AND PROTEIN CONJUGATE FOR DIABETES TREATMENT, AND APPLICATIONS THEREOF

The present invention relates to the field of biopharmaceutics, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two pol

ALBUMIN-BINDING COMPOUNDS

The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.

Long chain carboxylic acid maleimides

Provided are novel superoxide dismutase derivatives represented by the following general formula (I) STR1 wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R)- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species. Also provided are chemical modifiers to prepare the above SOD derivatives.

Superoxide dismutase derivatives

Provided are novel superoxide dismutase derivatives represented by the following general formula (I) wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R)- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species. Also provided are chemical modifiers to prepare the above SOD derivatives.