72849-35-5

Usage

Uses

Used in Cosmetics and Personal Care Products:
Octadecanedioic acid, 1-methyl ester is used as a fragrance ingredient in cosmetics, soaps, and other personal care products. Its pleasant scent and solubility in organic solvents make it a suitable ingredient for these applications.
Used in Chemical Manufacturing:
Octadecanedioic acid, 1-methyl ester serves as an intermediate in the manufacture of other chemicals. Its versatile chemical properties allow it to be used in the synthesis of various compounds.
Used in the Automotive Industry:
In the automotive industry, Octadecanedioic acid, 1-methyl ester is used as a lubricant additive. Its properties contribute to the performance and longevity of lubricants, enhancing the efficiency and durability of engines and machinery.

InChI:InChI=1/C19H36O4/c1-23-19(22)17-15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18(20)21/h2-17H2,1H3,(H,20,21)

Upstream product

• 1472-93-1 dimethyl 1,18-octadecanedioate 
• 42235-38-1 1,18-octadecanoic acid dimethyl ester 
• 2380-16-7 methyl 18-hydroxyoctadecanoate 
• 18654-84-7 17-octadecenoic acid methyl ester 
• 112-62-9 Methyl oleate 
• 871-70-5 octadecanedioic acid 
• 818-88-2 sebacic acid mono methyl ester 

Downstream Products

• 57-11-4 stearic acid 
• 871-70-5 octadecanedioic acid 
• 112-85-6 n-docosanoic acid 
• 17437-24-0 18-aminooctadecanoic acid 
• 2380-32-7 methyl 17-oxooctadecanoate 
• 72849-42-4 heptadecanedioic acid monomethyl ester 
• 2424-90-0 heptadecanedioic acid 

Relevant academic research and scientific papers

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor

Dimeric peptide-based inhibitors of postsynaptic density-95 (PSD-95) can reduce ischemic brain damage and inflammatory pain in rodents. To modify the pharmacokinetic profile, we designed a series of fatty acid linked dimeric ligands, which potently inhibits PSD-95 and shows improved in vitro blood plasma stability. Subcutaneous administration in rats showed extended stability and sustained release of these ligands. This can facilitate new pharmacological uses of PSD-95 inhibitors and further exploration of PSD-95 as a drug target.

COMPOUND COMPRISING A NUCLEIC ACID AND A HALF-LIFE EXTENSION MOTIF

Disclosed herein are compounds including a nucleic acid (A), their preparation, and their use.

Preparation method of surfactant

The invention provides a preparation method of a surfactant, specifically comprising the following four steps: 1, preparing an intermediate 1 by using methyl oleate as a raw material; 2, letting the intermediate 1 firstly react with borane in a solvent, then oxidizing with hydrogen peroxide, and finally performing alkaline hydrolysis to obtain an intermediate 2; 3, jointly oxidizing the intermediate 2 into an intermediate 3 in a solvent by sodium hypochlorite, sodium perchlorate and TEMPO (2, 2, 6, 6-tetramethylpiperidine-1-oxy CAS number: 2564-83-2); and 4, hydrolyzing the intermediate 3 in asolvent under an alkaline condition, and acidifying to obtain the surfactant octadecanedioic acid. The preparation method is a synthetic method including four steps of chemical reactions, and can efficiently convert methyl oleate into octadecanedioic acid. The method is simple to operate; and the reagent is cheap and easily available, green and safe, efficient and environmentally-friendly, and suitable for industrial production.

Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells

Lactosylceramide [LacCer; β-Gal-(1-4)-β-Glc-(1-1)-Cer] has been shown to contain very long fatty acids that specifically modulate neutrophil properties. The interactions between LacCer and proteins and their role in cell signaling processes were assessed