174399-96-3

Upstream product

• 174399-76-9 thioacetic acid S-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-methylsulfanylmethoxymethyl-tetrahydro-furan-3-yl] ester 
• 115913-88-7 3'-(acetylthio)-2',3'-dideoxythymidine 
• 174399-98-5 thioacetic acid S-[2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 

Downstream Products

• 221353-80-6 C₆₉H₈₂N₈O₁₉S₄ 
• 174399-81-6 C₅₈H₆₈N₆O₁₅S₃ 
• 174399-79-2 C₄₇H₅₄N₄O₁₁S₂ 
• 174399-97-4 Diphenyl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester 

Relevant academic research and scientific papers

Synthesis and hybridization property of an oligonucleotide containing a 3'-thioformacetal linked pentathymidylate

A pentathymidylate fully substituted with 3'-thioformacetal internucleotidic linkages was synthesized and subsequently incorporated into an oligonucleotide (ON) 15mer. Tm analysis was performed on the resulting ON hybridized with its complementary RNA. This duplex demonstrated slightly improved binding affinity relative to the control phosphate diester ON/RNA hybrid.