174457-99-9

Basic information

• Product Name: H-D-Asp(OBzl)-OBzl.HCl
• Synonyms: H-D-Asp(OBzl)-OBzl.HCl;Dibenzyl D-aspartate hydrochloride;D-aspartate Dibenzyl hydrochloride
• CAS NO: 174457-99-9
• Molecular Formula: C18H20ClNO4
• Molecular Weight: 349.8087
• Mol File: 174457-99-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: H-D-Asp(OBzl)-OBzl.HCl(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Asp(OBzl)-OBzl.HCl(174457-99-9)
• EPA Substance Registry System: H-D-Asp(OBzl)-OBzl.HCl(174457-99-9)

Safety Data

• Hazardous Substances Data: 174457-99-9(Hazardous Substances Data)

Usage

General Description

H-D-Asp(OBzl)-OBzl.HCl is a chemical compound with the molecular formula C18H24ClNO6. It is also known as Nα-Benzyloxycarbonyl-L-aspartic acid, and is a derivative of the amino acid aspartic acid. H-D-Asp(OBzl)-OBzl.HCl is often used as a reagent in peptide synthesis and as a catalyst in organic chemical reactions. It is commonly used in the research and development of pharmaceuticals and biotechnology products. H-D-Asp(OBzl)-OBzl.HCl is a white to off-white crystalline powder that is sparingly soluble in water, and should be handled and stored with care in accordance with standard laboratory practices and safety guidelines.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 56-84-8 L-Aspartic acid 
• 100-51-6 benzyl alcohol 
• 2886-33-1 dibenzyl L-aspartate toluene-4-sulphonate 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 80974-42-1 (S)-N-tert-butyloxycarbonylaspartic acid dibenzyl ester 

Downstream Products

• 122517-23-1 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-aspartic acid dibenzyl ester 

Relevant articles and documents

A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis

Based on DOCK scores 18 N-(3-benzyloxycarbonylcarboline-1-yl)ethylamino acid benzylesters (6a-r) were synthesized as anti-tumor agents. Their IC 50 values against five human carcinoma cell lines ranged from 11.1 μM to more than 100 μM. The in vivo assay identified five derivatives of them had no anti-tumor action, the anti-tumor activity of nine derivatives of them equaled that of cytarabine, and the anti-tumor activity of three derivatives of them was higher than that of cytarabine. The UV and fluorescence spectra, as well as the relative viscosity and melting temperature measurements of calf thymus DNA (CT DNA) with and without the representative compound suggested that DNA intercalation could be their action mechanism. The 3D QSAR analysis of N-(3-benzyloxycarbonylcarboline-1-yl)ethylamino acid benzylesters (6a-r) revealed that their in vivo anti-tumor activity significantly depends on the molecular electrostatic and steric fields of the side chain of the amino acid residue.