174468-63-4Relevant academic research and scientific papers
SUBSTITUTED BENZIMIDAZOLES. Part I. SYNTHESIS AND PROPERTIES OF SOME 2-ARYL-5-FLUORO-6-(4-METHYL-1-PIPERAZINYL)-1H-BENZIMIDAZOLES
El-Abadelah, Mustafa M.,Sabri, Salim S.,Zarga, Musa H. Abu,Abdel-Jalil, Raid J.
, p. 2713 - 2728 (2007/10/03)
2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde.The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k).However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration /= 100 μg/ml.
