174468-98-5

Upstream product

• 615-43-0 2-iodophenylamine 
• 28240-66-6 1,3-bis(phenylphosphano)propane 
• 109-64-8 1,3-dibromo-propane 
• 67405-21-4 (+/-)-(2-Aminophenyl)phenylphosphine 
• 142-28-9 1,3-Dichloropropane 
• 65423-44-1 (2-diphenylphosphino)benzeneamine 

Relevant academic research and scientific papers

Mono- and dinuclear pincer nickel catalyzed activation and transformation of C-Cl, C-N, and C-O bonds

Condensation of 2-NH2C6H4P(Et)Ph (2) with pyrrole-2-carboxaldehyde generated 2-(C4H4N-2′-CH - N)C6H4P(Et)Ph (3). Treatment of 3 with NaH and followed by (DME)NiX2 (X = Cl, Br) afforded mononuclear pincer nickel complexes [Ni{2-(C4H3N-2′-CH - N)C6H4P(Et)Ph}X] (4a, X = Cl; 4b, X = Br). Reaction of [2-NH2C6H4P(Ph)]2(CH2)n (5a, n = 3; 5b, n = 4) with pyrrole-2-carboxaldehyde or 5-tert-butyl-1H-pyrrole-2-carbaldehyde formed [2-(C4H4N-2′-CH - N)C6H4P(Ph)]2(CH2)n (6a, n = 3; 6b, n = 4) and [2-(5′-tBuC4H3N-2′-CH - N)C6H4P(Ph)]2(CH2)4 (6c). Respective treatment of 6a-c with NaH followed by (DME)NiX2 (X = Cl, Br) gave the dinuclear nickel complexes [Ni{2-(5′-RC4H2N-2′-CH - N)C6H4P(Ph)}X]2(CH2)n (7a, R = H, X = Cl, n = 3; 7b, R = H, X = Cl, n = 4; 7c, R = H, X = Br, n = 4; 7d, R = tBu, X = Cl, n = 4). Catalysis of the complexes for the activation and transformation of C-Cl, C-N, and C-O bonds was evaluated. Complex 7c exhibited excellent catalytic activity in the cross-coupling of aryl chlorides or aryltrimethylammonium iodides with arylzinc reagents as well as of aryl sulfamates with aryl Grignard reagents. The dinuclear nickel complexes 7b-d showed higher catalytic activity than the mononuclear complexes in each type of reaction.

Synthesis of bis[palladium(II)] and bis[platinum(II)] complexes containing chiral, linear quadridentate ligands with a P2N2 donor set

A number of bis[palladium(II)] and bis[platinum(II)] complexes of the type [(MCl2)2(μ-quadridentate)] [where M = Pd(II) or Pt(II)] and [(PtClMe)2(μ-quadridentate)] have been prepared containing the linear quadridentate NPP

Water soluble phosphines Part XV. Syntheses of multiply functionalized and chiral phospine ligands by Pd-catalyzed P-C and C-C coupling reactions

Phosphine ligands containing mono- and multiply substituted aromatic substituents (1-13, 19a and 19b) are accessible in high yields by palladium-catalyzed P-C coupling reactions between primary, secondary or disecondary phosphines and iodo- or bromoaromatic compounds. The reaction is of broad applicability and compatible with electron donor or electron acceptor substituents in ortho, meta or para position to the halogen in the aromatic ring systems. It may be performed in protic and aprotic solvents. The chiral spirocyclic boronato complex 15a is formed upon reaction of 3 with boric acid, while with benzeneboronic acid 15c with a peripheral Lewis acid group is obtained. The Pd-mediated P-C coupling reaction of primary phosphines proceeds stepwise, tailor-made chiral secondary (16) and tertiary phosphines (17) being formed in high yield. Through combination with Suzuki-type C-C coupling reactions, the scope of Pd-catalyzed P-C coupling may be extended further, novel ligands (20a, 20b, 21a, 21b) with biphenylyl substituents being accessible. The X-ray structures of the salicylic acid derivative 3 (space group P1) and of ortho-iso-propylphenyl-diphenylphosphine 6 (space group Pbca) have been determined.

SYNTHESIS OF 17- AND 21-MEMBERED MACROCYCLES INCORPORATING THE CHIRAL 1,1'-BINAPHTHYL BACKBONE AND NITROGEN, OXYGEN, AND PHOSPHORUS DONOR ATOMS

A 17-membered diaza-diphospha- and a 21-membered diaza-dioxa-diphospha-macrocycle (6) and (12), respectively, including the inherent chiral binaphthyl moiety were synthesized.Titanium(IV) mediated cyclization of 1,1'-binaphthyl-2,2'-dicarbaldehyde (4) wit

Transition Metal-mediated Discrimination between Diastereoisomers of a New Linear P2N2 Ligand, L1; X-Ray Structure Analysis of rac-L1, Cl*2H2O, and an Unusual RhI Dimer *2H2O

The new linear P2N2 ligand 1,3-bispropane, L1, as synthesised by reaction of (o-aminophenyl)diphenylphosphine, L2, with lithium and 1,3-dichloropropane, forms racemic and meso isomers with distinctly different stereochemica