174485-04-2Relevant academic research and scientific papers
PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS
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, (2008/06/13)
The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1
Structure-based design of novel HIV protease inhibitors: Sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors
Thaisrivongs, Suvit,Janakiraman, Musiri N.,Chong, Kong-Teck,Tomich, Paul K.,Dolak, Lester A.,Turner, Steve R.,Strohbach, Joseph W.,Lynn, Janet C.,Horng, Miao-Miao,Hinshaw, Roger R.,Watenpaugh, Keith D.
, p. 2400 - 2410 (2007/10/03)
The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously identif
