174487-85-5Relevant academic research and scientific papers
Synthesis of novel quinazoline-based antifolates with modified glutamate side chains as potential inhibitors of thymidylate synthase and antitumour agents
Bavetsias, Vassilios,Bisset, Graham M. F.,Kimbell, Rosemary,Boyle, F. Thomas,Jackman, Ann L.
, p. 13383 - 13396 (1997)
Several novel antifolates, derivatives of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid, were synthesised as inhibitors of thymidylate synthase (TS) and antitumour agents. This was accomplished by first developing routes to the key in
