Synthesis of novel quinazoline-based antifolates with modified glutamate side chains as potential inhibitors of thymidylate synthase and antitumour agents

DOI: 10.1016/S0040-4020(97)00851-X

Source and publish data:

Tetrahedron p. 13383 - 13396 (1997)

Update date:2022-08-03

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Authors:

Bavetsias, Vassilios

Bisset, Graham M. F.

Kimbell, Rosemary

Boyle, F. Thomas

Jackman, Ann L.

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Article abstract of DOI:10.1016/S0040-4020(97)00851-X

Several novel antifolates, derivatives of 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazafolic acid, were synthesised as inhibitors of thymidylate synthase (TS) and antitumour agents. This was accomplished by first developing routes to the key in

Full text of DOI:10.1016/S0040-4020(97)00851-X

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