1745-54-6

Basic information

• Product Name: 6,11-dihydrodibenzo[b,e]thiepine-11-carbonitrile
• Synonyms: 6,11-dihydrodibenzo[b,e]thiepine-11-carbonitrile
• CAS NO: 1745-54-6
• Molecular Formula: C₁₅H₁₁NS
• Molecular Weight: 237.31954
• Mol File: 1745-54-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,11-dihydrodibenzo[b,e]thiepine-11-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6,11-dihydrodibenzo[b,e]thiepine-11-carbonitrile(1745-54-6)
• EPA Substance Registry System: 6,11-dihydrodibenzo[b,e]thiepine-11-carbonitrile(1745-54-6)

Safety Data

• Hazardous Substances Data: 1745-54-6(Hazardous Substances Data)

Upstream product

• 1745-49-9 11-chloro-6,11-dihydro-dibenzo[b,e]thiepin 
• 7677-24-9 trimethylsilyl cyanide 
• 506-64-9 silver(I) cyanide 

Downstream Products

• 345941-23-3 11-<3-(tetrahydro-2-pyranyloxy)propyl>-6,11-dihydrodibenzothiepin-11-carbonitrile 
• 1531-77-7 dibenzo[b,e]thiepin-11(6H)-one 
• 84-65-1 9,10-phenanthrenequinone 
• 232613-90-0 VUF 5727 
• 82394-01-2 (6,11-dihydrodibenzothiepin-11-yl)methylamine 
• 87997-46-4 11-(3-dimethylaminopropyl)-6,11-dihydrodibenzothiepin-11-carbonitrile 

Relevant articles and documents

New Triazine Derivatives as Potent Modulators of Multidrug Resistance

A series of 70 triazine derivatives have been synthesized and tested for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity.Among the 12 selected compounds, 16 (S9788) showed high MDR reversing properties in vitro (300- and 6-fold VRP at 5μM in DC-3F/AD and KB-A1 cells, respectively) and induced a strong accumulation of adriamycin.The relationship between the increase of ADR accumulation and the fold reversal induced by these compounds and their lack of effects on the sensitive DC-3F cells suggest that they act mainly by inhibiting the P-glycoprotein (Pgp) catalyzed efflux of cytotoxic agents, as already described for a majority of MDR modulators.In vivo, in association with the antitumor drug vincristine (0.25 mg/kg), 16 (100 mg/kg) increased the T/C by 39percent in mice bearing the resistant tumor cell line P388/VCR.According to these interesting properties, 16 was selected for a clinical development because it is more bioavailable than 34, even though it was less active.

Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use

The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula STR1 wherein R is STR2 where R4 is a hydrogen or an alkyl; R1 is hydrogen or alkyl; R2 and R3 are the same or different and are hydrogen, alkyl or R2 and R3 are fused to form a pyrrolidino, morpholino, piperidino or azepino ring substituent; Y is hydrogen, halogen and alkoxy, X is STR3 where R4 is as defined above; m is an integer of 0 or 1; and n is an integer of 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.