17450-29-2

Basic information

• Product Name: 1-HEXYL-PYRROLE-2,5-DIONE
• Synonyms: 1-hexyl-1H-pyrrole-2,5-dione
• CAS NO: 17450-29-2
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• Mol File: 17450-29-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-HEXYL-PYRROLE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HEXYL-PYRROLE-2,5-DIONE(17450-29-2)
• EPA Substance Registry System: 1-HEXYL-PYRROLE-2,5-DIONE(17450-29-2)

Safety Data

• Hazardous Substances Data: 17450-29-2(Hazardous Substances Data)

Usage

Pyrrole derivative

A compound derived from pyrrole, which is a five-membered ring structure with one nitrogen atom.

Heterocyclic structure

A ring structure containing more than one type of atom, in this case, carbon and nitrogen.

Common use as a precursor

1-HEXYL-PYRROLE-2,5-DIONE is often used as a starting material in the synthesis of various pharmaceuticals and agrochemicals.

Potential use in organic electronics

The compound has been studied for its possible applications in the field of organic electronics due to its unique properties.

Component in redox flow batteries

1-HEXYL-PYRROLE-2,5-DIONE has been researched for its electrochemical properties, which could make it suitable for use in redox flow batteries.

Inhibition of amyloid-beta aggregation

The compound has been investigated for its ability to prevent the aggregation of amyloid-beta proteins, which are associated with neurodegenerative diseases like Alzheimer's.

Potential treatment for neurodegenerative diseases

Due to its ability to inhibit amyloid-beta aggregation, 1-HEXYL-PYRROLE-2,5-DIONE may be a candidate for the development of treatments for Alzheimer's and other neurodegenerative diseases.

Upstream product

• 541-59-3 maleiimide 
• 111-27-3 hexan-1-ol 
• 108-31-6 maleic anhydride 
• 111-26-2 hexan-1-amine 
• 55750-48-6 N-methoxycarbonylmaleimide 

Downstream Products

• 97725-90-1 4-<2-Diaethylphosphono-vinyl>-cyclohexen-1-phosphonsaeure-(3)-diaethylester 
• 1160847-94-8 ethyl 2-((S)-1-hexyl-2,5-dioxopyrrolidin-3-yl)-3-oxo-3-phenylpropanoate 
• 1166838-48-7 C₂₁H₂₆FNO₅ 

Relevant articles and documents

A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects

Glucagon has plenty of effects via a specific glucagon receptor(GCGR) like elevating the blood glucose, improving fatty acids metabolism, energy expenditure and increasing lipolysis in adipose tissue. The most important role of glucagon is to regulate the blood glucose, but the emergent possibilities of hyperglycaemia is exist. Glucagon could also slightly activate glucagon-like peptide-1 receptor(GLP-1R), which lead to blood glucose lowering effect. This study aims to erase the likelihood of hyperglycaemia and to remain the inherent catabolic effects through improving GLP-1R activation and deteriorating GCGR activation so as to lower the bodyweight and show diabetes-protective effects. Firstly, twelve cysteine modified GLP-1/GCGR dual agonists were synthesized (1–12). Then, the GLP-1R/GCGR mediated activation and biological activity in normal ICR mice were comprehensively performed. Compounds substituted by cysteine at positions 22, 23 and 25 in glucagon were observed to be better regulators of the body weight and blood glucose. To prolong the half-lives of derivatives, various fatty side chain maleimides were modified to optimal glucagon analogues. Laurate maleimide conjugate 4d was the most potent. Administration of 1000 nmol/kg 4d once every two days for a month normalized adiposity and glucose tolerance in diet-induced obese (DIO) mice. Improvements in plasma metabolic parameters including insulin, leptin, and adiponectin were observed. These studies suggest that compound 4d behaves well in lowering body weight and maintaining energy expenditure without a chance of hyperglycaemia, 4d has strong clinical potential as an efficient GLP-1/GCGR agonist in the prevention and treatment of obesity and dyslipidemia.

One-Pot Double-Annulation Strategy for the Synthesis of Unusual Fused Bis-Heterocycles

A novel metal-free double-annulation cascade for the construction of unusual fused heterocyclic systems is described. This simple protocol enables the sequential assembly of two rings in one pot from two simple precursors. Acidic conditions promote the condensation and the intramolecular alkynyl Prins reaction of an enyne or arenyne alcohol with a cyclic hemiaminal to form a five-, six-, or seven-membered oxacycle followed by a seven-or eight-membered azacycle. In this transformation, chemical complexity is rapidly generated with the formation of three new bonds (one C-O, one C-C, and one C-N) in one synthetic operation. The strategy is modular and relatively general, providing access to a series of unique fused bicyclic scaffolds.

BENZOBIS-(THIADIAZOLE) DERIVATIVE, INK CONTAINING THE SAME, AND ORGANIC ELECTRONICS DEVICE USING THE SAME

The object of the present invention is to provide a benzobis-(thiadiazole) derivative which has excellent electron mobility (field-effect mobility) and excellent stability in the atmosphere. The present invention relates to a benzobis-(thiadiazole) derivative which has a cyclic imide structure with condensed aromatic ring in its molecule shown in the formula (1) or (2): (In the formula, R, A and Z represent specific groups.)