55750-48-6Relevant articles and documents
Linker, linker-containing antibody conjugate drug and application of linker
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Paragraph 0171-0173; 0183-0186, (2020/02/20)
The invention relates to a linker as shown in a formula I, a linker-containing antibody conjugate drug and an application of the linker, also relates to a pharmaceutical composition comprising the antibody conjugate drug, and also relates to an application of the antibody conjugate drug to the treatment and/or prevention of diseases.
Anisotropic dynamics and mechanics of macromolecular crystals containing lattice-patterned polymer networks
Han, Kenneth,Bailey, Jake B.,Zhang, Ling,Tezcan, F. Akif
supporting information, p. 19402 - 19410 (2020/11/13)
The mechanical and functional properties of many crystalline materials depend on cooperative changes in lattice arrangements in response to external perturbations. However, the flexibility and adaptiveness of crystalline materials are limited. Additionally, the bottom-up, molecular-level design of crystals with desired dynamic and mechanical properties at the macroscopic level remains a considerable challenge. To address these challenges, we had previously integrated mesoporous, cubic ferritin crystals with hydrogel networks, resulting in hybrid materials (polymer-integrated crystals or PIX) which could undergo dramatic structural changes while maintaining crystalline periodicity and display efficient self-healing. The dynamics and mechanics of these ferritin-PIX were devoid of directionality, which is an important attribute of many molecular and macroscopic materials/devices. In this study, we report that such directionality can be achieved through the use of ferritin crystals with anisotropic symmetries (rhombohedral or trigonal), which enable the templated formation of patterned hydrogel networks in crystallo. The resulting PIX expand and contract anisotropically without losing crystallinity, undergo prompt bending motions in response to stimuli, and self-heal efficiently, capturing some of the essential features of sophisticated biological devices like skeletal muscles.
Poly[(side-on mesogen)-Alt-(end-on mesogen)]: A compromised molecular arrangement
Wang, Meng,Bao, Wei-Wei,Chang, Wen-Ying,Chen, Xu-Man,Lin, Bao-Ping,Yang, Hong,Chen, Er-Qiang
, p. 5791 - 5800 (2019/08/26)
In recent years, sequence-controlled side-chain liquid crystal polymers (SCLCPs) have gained extensive interest because mesogenic units with different lengths and distributions can form various ordered sequences, which further endow LCP materials with diverse functions. In this manuscript, a side-chain side-on maleimide-containing monomer 2,5-bis-(4-butoxy-benzoyloxy)-benzoic acid 6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl ester (Y1801) and a side-chain end-on styrene-containing monomer 4′-[6-(4-vinyl-phenoxy)-hexyloxy]-biphenyl-4-carbonitrile (Y1802) are combined in one single macromolecular chain and orderly polymerized in an alternative sequence to form an alternating copolymer Poly(Y1801-Alt-Y1802). The chemical structure and alternating sequence of Poly(Y1801-Alt-Y1802) are confirmed by GPC and NMR techniques. The combination of DSC, POM, and WAXS data indicates that, although the side-on homopolymer PY1801 and the end-on homopolymer PY1802 both exhibit the nematic phase, their alternating copolymer Poly(Y1801-Alt-Y1802) shows an interdigitated smectic A phase, a compromised molecular arrangement instead. In addition, a strong fluorescence emission of Poly(Y1801-Alt-Y1802) is observed, which might provide this novel alternating-structured liquid crystal polymer with potential applications in luminescent materials and devices.
