17450-30-5

Basic information

• Product Name: 1-octadecyl-1H-pyrrole-2,5-dione
• Synonyms: 1-octadecyl-1H-pyrrole-2,5-dione;1-Octadecyl-3-pyrroline-2,5-dione;N-Stearylmaleimide;Einecs 241-467-2
• CAS NO: 17450-30-5
• Molecular Formula: C₂₂H₃₉NO₂
• Molecular Weight: 349.55056
• EINECS: 241-467-2
• Mol File: 17450-30-5.mol

Chemical Properties

• Boiling Point: 455.4°C at 760 mmHg
• Flash Point: 164.2°C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 1.76E-08mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: 1-octadecyl-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-octadecyl-1H-pyrrole-2,5-dione(17450-30-5)
• EPA Substance Registry System: 1-octadecyl-1H-pyrrole-2,5-dione(17450-30-5)

Safety Data

• Hazardous Substances Data: 17450-30-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Octadecyl-1H-pyrrole-2,5-dione is used as an anti-inflammatory agent for the treatment of asthma and allergic conjunctivitis. It functions by stabilizing mast cell membranes, thereby preventing the release of inflammatory substances in response to allergens, which helps in managing and preventing the symptoms associated with these conditions.
Used in Respiratory Therapy:
Nedocromil is used as a bronchodilator and anti-inflammatory in the treatment of asthma. It helps to reduce airway inflammation and constriction, providing relief from asthma symptoms and improving lung function.
Used in Ophthalmic Treatments:
In the form of ophthalmic solutions, 1-octadecyl-1H-pyrrole-2,5-dione is used for the treatment of allergic conjunctivitis. It alleviates the ocular symptoms of allergies, such as itching, redness, and swelling, by reducing the inflammatory response.
Used in Allergy Management:
Nedocromil is utilized as an anti-allergic medication to help control allergic reactions by inhibiting the release of histamine and other mediators, which are responsible for the symptoms of allergies.

InChI:InChI=1/C22H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-23-21(24)18-19-22(23)25/h18-19H,2-17,20H2,1H3

Upstream product

• 3077-27-8 (N-octadecyl)maleamic acid 

Downstream Products

• 111363-48-5 N-1-octadecyl-3-<(N,N-dibenzylamino)oxy>pyrrolidine-2,5-dione 
• 111024-69-2 3-(3,5-di-t-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione 
• 111024-62-5 diastereoisomers of 3-(3,5-dimethyl-4-hydroxyphenyl)-3-(1-n-octadecyl-2,5-dioxopyrrolidin-3-yl)-1-n-octadecylpyrrolidine-2,5-dione 

Relevant articles and documents

Drug delivery system

A combination product comprising a positive oil in water emulsion wherein said emulsion comprises a compound presenting free NH2 groups, at its natural state, at the oil-water interface, and an antibody, wherein said compound is linked to said antibody by a heterobifunctional linker, linking said NH2 groups to SH groups on the antibody hinge region.

Process for preparation of N-substituted maleimides

N-substituted maleimide represented by formula (2): STR1 is produced from N-substituted maleamic acid monoester represented by formula (1): STR2 in the presence of an acid catalyst by elmination of an alcohol from the monoester. The above N-substituted maleamic acid monoester represented by formula (1) is produced by esterification of N-substituted maleamic acid represented by formula (3): STR3 with an alcohol R2 -OH in the represence of an acid catalyst.