3077-27-8

Usage

Flammability and Explosibility

Notclassified

InChI:InChI=1/C22H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-23-21(24)18-19-22(25)26/h18-19H,2-17,20H2,1H3,(H,23,24)(H,25,26)/b19-18+

Upstream product

• 108-31-6 maleic anhydride 
• 124-30-1 1-aminooctadecane 

Downstream Products

• 17450-30-5 N-n-octadecylmaleimide 

Relevant academic research and scientific papers

Compound, application thereof, platinum coordination complex and liposome thereof

The invention relates to the field of medicines, in particular to a compound, application thereof, a platinum coordination complex and liposome thereof. The platinum coordination complex disclosed by the invention can be well combined with a membrane material of the liposome, so that encapsulation efficiency and drug loading capacity of the liposome are improved; furthermore, the platinum coordination complex disclosed by the invention contains carboxyl and has pH sensitivity; the carboxyl trends to be deprotonated in lower pH value environment (such as tumor tissues), so that release of medicine in the tumor tissues is improved, and a curing effect of medicine is improved. Experiments show that the liposome disclosed by the invention can reduce toxic and side effects of the medicine and improve medicine effects.

Drug delivery system

A combination product comprising a positive oil in water emulsion wherein said emulsion comprises a compound presenting free NH2 groups, at its natural state, at the oil-water interface, and an antibody, wherein said compound is linked to said antibody by a heterobifunctional linker, linking said NH2 groups to SH groups on the antibody hinge region.