174505-05-6

Basic information

• Product Name: 5-hydroxy-11α-(4-methoxyphenyl)-11β,12β-epoxy-5α-androstane-3,17-dione cyclic bis(1,2-ethanediyl acetal)
• CAS NO: 174505-05-6
• Molecular Weight: 512.643
• Mol File: 174505-05-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-11α-(4-methoxyphenyl)-11β,12β-epoxy-5α-androstane-3,17-dione cyclic bis(1,2-ethanediyl acetal)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-11α-(4-methoxyphenyl)-11β,12β-epoxy-5α-androstane-3,17-dione cyclic bis(1,2-ethanediyl acetal)(174505-05-6)
• EPA Substance Registry System: 5-hydroxy-11α-(4-methoxyphenyl)-11β,12β-epoxy-5α-androstane-3,17-dione cyclic bis(1,2-ethanediyl acetal)(174505-05-6)

Safety Data

• Hazardous Substances Data: 174505-05-6(Hazardous Substances Data)

Upstream product

• 174505-01-2 (8'S,9’S,10'R,13’R,14'S)-10’,13’-dimethyl-11’-(((4,4,4,4,4,4,4,4,4-nonafluoro-4112-buta-1,3-diyn-1-yl)thio)trioxidanyl)-1‘,4’,7’,8’,9’,10’, 13’,14',15’,16’-decahydro-2’H-dispiro[[1,3]dioxolane-2,3‘-cyclopenta[a]phenanthrene-17',2”-[1,3]dioxolane] 
• 174505-03-4 (4a’R, 5a’S,6a’S,6b’S,9a’R,11a’R,11b’R)-11‘-(4-methoxyphenyl)-9a’,11b’-dimethyl-1’,5a’,6’,6a’,6b’,7’,8’,9a’,11a',11b’-decahydro-2’H,4’H-dispiro[[1,3]dioxolane-2,3‘-cyclopenta[1,2]phenanthro[8a,9-b]oxirene-9’,2”-[1,3]dioxolane] 
• 174505-02-3 (8’S,9’S,10'R,13‘R,14’S)-11‘-(4-methoxyphenyl)-10’,13‘-dimethyl-1‘,4’,7’,8’,9’,10’,13’,14',15’,16’-decahydro-2’H-dispiro[[1,3]dioxolane-2,3’-cyclopenta[a]phenanthrene-17’,2”-[1,3]dioxolane] 
• 13872-18-9 (8'S,9’S,10'R,13’S,14'S)-10’,13’-dimethyl-1',2',4',7',8',9',10’,12’,13’,14',15’,16’-dodecahydro-11’H-dispiro[[1,3]dioxolane-2,3’-cyclopenta[a]phenanthrene-17’,2”-[1,3]dioxolan]-11‘-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 174505-04-5 (5’R,8’S,9’R,10'R,13’R,14'S)-11’-(4-methoxyphenyl)-10’,13’-dimethyl-1‘,6’,7’,8’,9’,10’,13’,14',15’,16’-decahydro-2’H-dispiro[[1,3]dioxolane-2,3’-cyclopenta[a]phenanthrene-17’,2”-[1,3 ]dioxolan]-5’(4’H)-ol 

Downstream Products

• 174505-04-5 (5’R,8’S,9’R,10'R,13’R,14'S)-11’-(4-methoxyphenyl)-10’,13’-dimethyl-1‘,6’,7’,8’,9’,10’,13’,14',15’,16’-decahydro-2’H-dispiro[[1,3]dioxolane-2,3’-cyclopenta[a]phenanthrene-17’,2”-[1,3 ]dioxolan]-5’(4’H)-ol 

Relevant articles and documents

11β-aryl steroids in the androstene series. The role of the 11β-region in steroid progesterone receptor interaction

The syntheses of 11β-arylandrost-4-en-3-one 24 and the corresponding 9β,19-cyclo derivative 8 are described. Steric interaction between C-19 and the aryl residue effects conformational changes of the steroid ring system that result in reduced affinity for the progesterone receptor. The conformation of 11β-arylandrostenes is discussed in comparison with known antiprogestational steroids.