17451-67-1

Basic information

• Product Name: ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate
• Synonyms: ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate;(S)-1,3-Dihydro-α-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetic acid ethyl ester;2H-Isoindole-2-acetic acid, 1,3-dihydro-.alpha.-[(4-nitrophenyl)methyl]-1,3-dioxo-, ethyl ester, (S)-;4-Nitro-L-phenyl-N-phthalylalanine, ethyl ester;Nsc313358
• CAS NO: 17451-67-1
• Molecular Formula: C₁₉H₁₆N₂O₆
• Molecular Weight: 368.34014
• EINECS: 241-468-8
• Mol File: 17451-67-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 548°Cat760mmHg
• Flash Point: 285.2°C
• Appearance: /
• Density: 1.396g/cm³
• Refractive Index: 1.627
• CAS DataBase Reference: ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate(17451-67-1)
• EPA Substance Registry System: ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate(17451-67-1)

Safety Data

• Hazardous Substances Data: 17451-67-1(Hazardous Substances Data)

Usage

General Description

Ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate is a chemical compound with the molecular formula C18H15NO6. It is an ester, meaning it is derived from an alcohol and an organic acid. ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate has potential pharmaceutical properties and may be used in the development of therapeutic drugs or research into new treatment options. The presence of a nitro group and an isoindole ring in its structure suggests that it may have biological activity or be used as a precursor in the synthesis of biologically active compounds. However, it is crucial to handle this compound carefully, as nitro groups can be potentially explosive and are also toxic to humans and the environment.

InChI:InChI=1/C19H16N2O6/c1-2-27-19(24)16(11-12-7-9-13(10-8-12)21(25)26)20-17(22)14-5-3-4-6-15(14)18(20)23/h3-10,16H,2,11H2,1H3/t16-/m0/s1

Upstream product

• 22509-74-6 N-ethoxycarbonylphthalimide 
• 58816-66-3 (S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride 
• 36097-39-9 (S)-methyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 147065-06-3 L-nitrophenylalanine hydrochloride 
• 85-44-9 phthalic anhydride 
• 34276-53-4 ethyl (S)-2-amino-3-(4-nitrophenyl)propionate 
• 555-16-8 4-nitrobenzaldehdye 
• 207569-25-3 p-nitro-L-phenylalanine hydrate 
• 60666-01-5 (RS)-N-phthaloyl-p-nitrophenylalanine 
• 100-14-1 4-nitrobenzyl chloride 
• 855633-22-6 (4-nitro-benzyl)-phthalimido-malonic acid diethyl ester 
• 101445-16-3 N-(2-carboxy-benzoyl)-4-nitro-phenylalanine 
• 64-17-5 ethanol 
• 17451-66-0 N-phthaloyl-3-(4-nitrophenyl)-(S)-alanine 

Downstream Products

• 93942-39-3 C₂₃H₂₄Cl₂N₂O₄ 
• 97338-02-8 N-phthalimido-4-(bis-2-hydroxyethyl)amino-L-phenylalanine ethyl ester 
• 792864-20-1 N-phthalimido-4-(bis-2-chloroethyl)amino-L-phenylalanine ethyl ester 
• 3223-07-2 melphalan hydrochloride 
• 74743-23-0 N-phthalimido-4-amino-L-phenylalanine ethyl ester 
• 116604-67-2 4-ethylamino-N,N-phthaloyl-L-phenylalanin-ethyl ester 
• 100800-30-4 4-diethylamino-L-phenylalanine 
• 116604-68-3 4-dimethylamino-N,N-phthaloyl-L-phenylalanin-ethyl ester 
• 1195524-16-3 4-amino-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 116604-68-3 4-dimethylamino-N,N-phthaloyl-D-phenylalanin-ethyl ester 

Relevant articles and documents

A PROCESS FOR THE SYNTHESIS OF MELPHALAN

The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: -N(CH2CH2OS(O)nO-)2, wherein n is 1 or 2 followed by conversion of the –-N(CH2CH2OS(O)nO-)2 group into a -N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.

Synthesis process of N-paraphthalyl(diethanol)amino-L-phenylalanine ethyl ester

The invention provides a synthesis process of N-paraphthalyl(diethanol)amino-L-phenylalanine ethyl ester. The process includes the first step of amino protection reaction, the second step of esterification reaction, the third step of reduction reaction and the fourth step of substitution reaction. According to the synthesis process, amino is protected by phthalic anhydride, and then esterification, reduction and substitution are conducted obtain the product. The process has the advantages of being low in cost, mild in reaction condition, low in toxicity, convenient to operate, high in yield and suitable for industrial production.