17452-14-1

Basic information

• Product Name: 1-(4-METHOXYPHENYL)IMIDAZOLINE-2-THIONE
• Synonyms: 1-(4-METHOXYPHENYL)IMIDAZOLINE-2-THIONE;1-(4-Methoxyphenyl)-1,3-dihydro-2H-imidazole-2-thione;1-(4-Methoxyphenyl)-1H-iMidazole-2(3H)-thione
• CAS NO: 17452-14-1
• Molecular Formula: C₁₀H₁₀N₂OS
• Molecular Weight: 206.26
• Mol File: 17452-14-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 216-217°C
• Boiling Point: 336.6°Cat760mmHg
• Flash Point: 157.4°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.689
• BRN: 155898
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)IMIDAZOLINE-2-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)IMIDAZOLINE-2-THIONE(17452-14-1)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)IMIDAZOLINE-2-THIONE(17452-14-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 17452-14-1(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)imidazoline-2-thione is a chemical compound that belongs to the imidazoline derivative class. It is also known by its chemical name, 4-methoxyphenylimidazoline-2-thione. 1-(4-METHOXYPHENYL)IMIDAZOLINE-2-THIONE consists of a thione group attached to an imidazoline ring, with a methoxy group attached to the phenyl ring. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its ability to act as a ligand in metal-catalyzed reactions and its potential pharmacological activities. Additionally, it has been investigated for its potential antimicrobial and antifungal properties, making it a valuable compound in the fields of medicine and agriculture.

InChI:InChI=1/C10H10N2OS/c1-13-9-4-2-8(3-5-9)12-7-6-11-10(12)14/h2-7H,1H3,(H,11,14)

Upstream product

• 95333-84-9 N-(4-methoxyphenyl)-N'-(2,2-dimethoxyethyl)thioura 
• 3129-90-6 isothiocyanic acid 
• 625842-54-8 N-(2,2-diethoxyethyl)-4-methoxyaniline 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 688335-87-7 N-(2-fluorophenyl)-2-(1-(4-methoxyphenyl)-1H-imidazol-2-ylthio)acetamide 
• 1187945-95-4 N-(2-chlorophenyl)-2-(1-(4-methoxyphenyl)-1H-imidazol-2-ylthio)acetamide 
• 124627-82-3 2-(carboxymethylthio)-1-(4-methoxyphenyl)imidazole 
• 95333-67-8 1-(4-Hydroxy-phenyl)-1,3-dihydro-imidazole-2-thione 

Relevant articles and documents

Method for preparing cyclic thiourea compound

The method comprises the following steps: suspending metal hydride in anhydrous THF, dropwise adding ring thiourea in the stirring process, stirring at room temperature after completion of stirring, stirring at room temperature, TLC monitoring reaction co

New bis(mercaptoimidazolyl)(pyrazolyl)borate ligands and their zinc complex chemistry

Nine new tripodal NS2 ligands of the bis(mercaptoimidazolyl)(pyrazolyl)borate type with varying 3-R-mercaptoimidazolyl moieties were prepared as their potassium salts. Treatment with zinc salts yielded the complex types L·Zn-Cl, L·Zn-I, L·Zn-ONO2, L·Zn-OClO3 and [L·Zn(imidazole)]ClO4. Attempts at the formation of L·Zn-OH or cationic L·Zn complexes resulted in dismutation and formation of ZnL2 complexes. Hydrolytic destruction yielded one [OZn4(thiooimidazolate)6] complex. The ZnS2NO coordination which is present in the enzyme-substrate complex of alcohol dehydrogenase could be successfully modelled by an [L·Zn(C2H5OH)]+ complex. The L·Zn-X complexes showed very low catalytic activity in the dehydrogenation of 2-propanol or the hydrogenation of p-nitrobenzaldehyde. The new compounds were identified by a total of 12 structure determinations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors

Potent dopamine-β-hydroxylase inhibitors having the Formula STR1 that are useful to inhibit dopamine-β-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-β-hydroxylase ac