95333-84-9Relevant academic research and scientific papers
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
Zhan, Peng,Liu, Xinyong,Zhu, Junjie,Fang, Zengjun,Li, Zhenyu,Pannecouque, Christophe,Clercq, Erik De
experimental part, p. 5775 - 5781 (2009/12/28)
A series of 2-(1-aryl-1H-imidazol-2-ylthio)acetamide [imidazole thioacetanilide (ITA)] derivatives were synthesized and evaluated as potent inhibitors of human immunodeficiency virus type-1 (HIV-1). Among them, the most potent HIV-1 inhibitors were 4a5 (E
DOPAMINE-BETA-HYDROXYLASE INHIBITORS
-
, (2008/06/13)
Potent dopamine-beta-hydroxylase inhibitors having the Formula that are useful to inhibit dopamine-beta-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-beta-hydroxylas
Structure activity relationships in reactivators of organophosphorus inhibited acetylcholinesterase. VII. 1 Aryl 2 hydroxyiminomethyl 3 methylimidazolium iodides
Franchetti,Grifantini,Martelli,Stein
, p. 18 - 22,21,22 (2007/10/05)
A series of 1 aryl 2 hydroxyiminomethyl 3 methylimidazolium iodides, where the aryl group is either phenyl or substituted phenyl, was prepared and tested for their reactivating potency on phosphorylated acetylcholinesterase (AChE) and for anti AChE activity. The in vitro testing revealed that some of the new compounds are good reactivators. Correlations between their structure and biological activities have been attempted.
