17452-78-7

Basic information

• Product Name: 5-(p-tolyl)-1,3,4-oxathiazol-2-one
• Synonyms: 5-(p-tolyl)-1,3,4-oxathiazol-2-one
• CAS NO: 17452-78-7
• Molecular Weight: 193.226
• Mol File: 17452-78-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-(p-tolyl)-1,3,4-oxathiazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(p-tolyl)-1,3,4-oxathiazol-2-one(17452-78-7)
• EPA Substance Registry System: 5-(p-tolyl)-1,3,4-oxathiazol-2-one(17452-78-7)

Safety Data

• Hazardous Substances Data: 17452-78-7(Hazardous Substances Data)

Upstream product

• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 619-55-6 para-methylbenzamide 
• 52533-04-7 N-p-toluoyl-trichloromethanesulfenamide 

Downstream Products

• 1421922-35-1 5-(2,5-dimethyl-4-nitrobenzyl)-3-(4-methylphenyl)-1,2,4-thiadiazole 
• 1421922-36-2 2,5-dimethyl-4-{[3-(4-methylphenyl)-1,2,4-thiadiazol-5-yl]methyl}aniline 
• 20069-37-8 3-(4-tolyl)-1,2,4-thiadiazole-5-(2H)-thione 
• 1338682-63-5 3-(p-tolyl)isothiazole-5-carboxylic acid 
• 104-85-8 para-methylbenzonitrile 
• 67049-13-2 3-(p-tolyl)-4-isothiazolecarboxylic acid 
• 49602-78-0 3-(p-tolyl)isothiazole 
• 119-61-9 benzophenone 
• 117077-01-7 5,5-Diphenyl-3-p-tolyl-[1,4,2]dithiazole 
• 114246-37-6 ethyl 3-(p-tolyl)isothiazole-5-carboxylate 
• 120587-95-3 3,5-Diphenyl-[1,2,4]thiadiphosphole 
• 120587-92-0 3-p-Tolyl-5-trimethylsilanyl-[1,2,4]thiazaphosphole 
• 111479-61-9 5-(2,4-dinitrophenylseleno)-3-(4-tolyl)-1,2,4-thiadiazole 

Relevant articles and documents

Synthesis of spiroindene-1,3-dione isothiazolines via a cascade michael/1,3-dipolar cycloaddition reaction of 1,3,4-oxathiazol-2-one and 2-arylidene-1,3-indandiones

The reaction of 1,3,4-oxathiazol-2-one derivative with 2-arylidene-1,3-indandione to furnish novel spiroindene-1,3-dione isothiazoline derivatives by Michael/1,3-dipolar [3+2]-cycloaddition reaction was investigated. The key 1,3-dipolar cycloaddition reaction step was examined in toluene solvent at reflux temperature to obtain mixture of two regioisomers (6a and 6b – 14a and 14b) and single isomers (15–20). The scope of this new reaction was demonstrated with many examples with high reactivity and yields.

Non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: Study of structural requirements for thiadiazolidinone derivatives

The 2,4-disubstituted thiadiazolidinones (TDZD) were described as the first non-ATP competitive GSK-3β inhibitors. New modifications in this heterocyclic ring are here reported to study the influence on the biological activity. The basic skeleton of 1,2,4-thiadiazole and also one of the carbonyl groups are kept, while different modifications are introduced in positions 3 and 5, respectively. The GSK-3β activity of the new thiadiazole derivatives here synthesized showed IC50 values for some of the compounds in the micromolar range. Additionally, ATP competition studies have been carried out, showing that as well as the first generation of TDZD, these new compounds act in a non-competitive manner. With this study, additional requirements for the biological activity of the TDZD family have been delineated.

4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.