174535-76-3Relevant articles and documents
Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one
Guccione, Salvatora,Modica, Marie,Longmore, Jeanette,Shaw, David,Uccello Barretta, Gloria,Santagati, Andrea,Santagati, Maria,Rasso, Filippo
, p. 59 - 64 (2007/10/03)
1,6-Diphenyl-pyrazolo[3,4-d]thiazolo[3,2-a]4H-pyrimidin-4-one caused parallel displacement of the dose-response curve to the NK-2 receptor agonist in the guinea pig trachea suggesting it acts as a competitive antagonist. It is not active in the NK-1 and NK-3 receptor binding assays. A Ca++ channel blocking action at the voltage-operated channels (L-type) was observed.