156718-77-3

Upstream product

• 75-15-0 carbon disulfide 
• 50427-77-5 5-amino-1-phenyl-1H-pyrazole-4-carboxamide 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 17356-08-0 thiourea 
• 110810-00-9 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 532-55-8 Benzoyl isothiocyanate 
• 100-63-0 phenylhydrazine 
• 198715-88-7 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 198715-89-8 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [1-(4-chloro-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 58046-54-1 5-amino-1-phenyl-1H-pyrazole-4-carbohydrazide 
• 198716-01-7 1-Phenyl-6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d][1,3]thiazin-4-one 

Downstream Products

• 850911-53-4 6-allylsulfanyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one 
• 174535-73-0 2-(4-Hydroxy-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylsulfanyl)-1-phenyl-ethanone 
• 174535-76-3 1,6-Diphenyl-1H-pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one 

Relevant academic research and scientific papers

Biosynthesis of (MWCNTs)-COOH/CdO hybrid as an effective catalyst in the synthesis of pyrimidine-thione derivatives by water lily flower extract

Pink Water lily flower, with the scientific name of Nymphaea alba in the family of Nymphaeaceae, was collected from North of Iran, Mazandaran in spring, dried in shade and powdered. The powdered flower material was extracted in 70% (vol/vol) ethanol. Acid

Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one

1,6-Diphenyl-pyrazolo[3,4-d]thiazolo[3,2-a]4H-pyrimidin-4-one caused parallel displacement of the dose-response curve to the NK-2 receptor agonist in the guinea pig trachea suggesting it acts as a competitive antagonist. It is not active in the NK-1 and NK-3 receptor binding assays. A Ca++ channel blocking action at the voltage-operated channels (L-type) was observed.

COMPOUNDS HAVING PDE9A INHIBITORY ACTIVITY, AND PHARMACEUTICAL USES THEREOF

The present invention provides a compound having a specific chemical structure and having PDE9A inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention provides a composition containing the compound or a pharmaceutically acceptable salt thereof. The present invention provides a pharmaceutical use, for treating or preventing PDE9A-related diseases, of the compound according to the present invention, a salt thereof, and a composition containing the compound or salt. The present invention also provides a method for treating or preventing PDE9A-related diseases, the method comprising administering an effective amount of the compound according to the present invention, a salt thereof, or a composition containing the compound or salt to a subject in need of treatment.

KINASE INHIBITORS AND RELATED METHODS OF USE

The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as ΡIΜ kinases. The compounds can be used in methods of treating various disorders, including cancers.

Microwave-assisted synthesis of substituted pyrazoles and pyrazolo [3,4-d]thiopyrimidines

Ethyl(ethoxymethylene)cyanoacetate and ethoxymethylene malononitrile were synthesized from the reaction of malononitrile or ethylcyanoacetate with triethyl orthoformate or orthoacetate in N, N-dimethylacetamide under microwave irradiation. In a similar manner, substituted pyrazoles were synthesized from the reaction of ethyl (ethoxymethylene)cyanoacetate and ethoxymethylene malononitrile with phenylhydrazine. These pyrazoles were converted to pyrazolo[3,4-d]thiopyrimidines upon treatment with arylisothiocyanate and thiourea under microwave irradiation. Copyright Taylor & Francis Group, LLC.

Syntheis of Some New Pyrazolotriazines, Pyrazolothiazines and Pyrazolopyrimidines

When the pyrazole derivatives 3a,b were treated with triethyl orthoformate, the pyrazolotriazinethiones 5a,b were obtained.These were S-alkylated to give compounds 6a-d.Treatment of 5a,b with hydrazine hydrate in ethanol afforded 7,8 respectively.Benzylid