174541-89-0Relevant articles and documents
A straightforward synthesis of (2S,3R)-3-hydroxyproline and trans-(2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine
Dell'Uomo, Natalina,Di Giovanni, Maria Cristina,Misiti, Domenico,Zappia, Giovanni,Delle Monache, Giuliano
, p. 181 - 188 (2007/10/03)
A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has been introduced by a modified Mitsunobu reaction.