174575-17-8

Basic information

• Product Name: SDZ 220-581
• Synonyms: (S)-ALPHA-AMINO-2'-CHLORO-5-(PHOSPHONOMETHYL)[1,1'-BIPHENYL]-3-PROPANOIC ACID;SDZ 220-581;alpha-Amino-2'-chloro-5-(phosphonomethyl)(1,1'-biphenyl)-3-propanoic acid;(S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoicacid
• CAS NO: 174575-17-8
• Molecular Formula: C16H20ClN2O5P
• Molecular Weight: 386.77
• Product Categories: Glutamate receptor
• Mol File: 174575-17-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 613.3°C at 760 mmHg
• Flash Point: 324.7°C
• Appearance: /
• Density: 1.478
• Vapor Pressure: 6.75E-16mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: Store at RT
• PKA: 1.63±0.10(Predicted)
• CAS DataBase Reference: SDZ 220-581(CAS DataBase Reference)
• NIST Chemistry Reference: SDZ 220-581(174575-17-8)
• EPA Substance Registry System: SDZ 220-581(174575-17-8)

Safety Data

• Hazardous Substances Data: 174575-17-8(Hazardous Substances Data)

Usage

Uses

SDZ 220-581 is a competitive NMDA receptor antagonist.

Biological Activity

Competitive NMDA receptor antagonist (pK i = 7.7). Centrally active following oral administration (ED 50 < 3.2 mg/kg for protection against MES-induced seizures).

InChI:InChI=1/C16H17ClNO5P/c17-14-4-2-1-3-13(14)12-6-10(8-15(18)16(19)20)5-11(7-12)9-24(21,22)23/h1-7,15H,8-9,18H2,(H,19,20)(H2,21,22,23)/t15-/m0/s1

Upstream product

• 174575-08-7 1,1-dimethylethyl (2S,5S)-5-<<2'-chloro-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate 
• 174575-06-5 1,1-dimethylethyl (2S,5S)-5-<<3-bromo-5-<(diethoxyphosphoryl)methyl>phenyl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate 
• 174575-03-2 diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate 
• 51760-22-6 5-bromo-1,3-dihydroxymethylbenzene 
• 51760-23-7 1-bromo-3,5-bis(bromomethyl)benzene 

Relevant articles and documents

Syntheses of biphenyl analogues of AP7, a new class of competitive N-methyl-D-aspartate (NMDA) receptor antagonists

Affinities for the NMDA receptor were measured ([3H]CGP-39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional test (rat neocortical slice preparation). Structure-activity relationships show that attachment