174590-90-0

Upstream product

• 130222-84-3 5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone 
• 591-51-5 phenyllithium 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 500229-14-1 (3aR,6R,6aR)-6-Hydroxymethyl-2,2-dimethyl-4-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol 
• 141979-56-8 1,5-O-diacetyl-2,3-O-isopropylidene-D-ribofuranoside 
• 108-86-1 bromobenzene 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 
• 32257-17-3 5-Acetyl-2,3-O-isopropyliden-D-ribonolactone 
• 532-20-7 D-Ribose 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 

Downstream Products

• 177471-62-4 tert-butyl(((3aR,4R,6S,6aS)-2,2-dimethyl-6-phenyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)diphenylsilane 
• 389633-39-0 α-(1R,5R,8R)-3,3-dimethyl-6-phenyl-6-(2'-propenyl)-8-(tert-butyldiphenylsilyloxymethyl)-2,4,7-trioxabicyclo[3.3.0]octane 
• 389633-46-9 [(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-4-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-acetaldehyde 
• 660410-69-5 (1'S,3'R,4'R,5'R,7'S)-N²-isobutyryl-7-(4'-hydroxy-3'-hydroxymethyl-1'-phenyl-2',6'-dioxabicyclo[3.3.0]oct-7'-yl)guanine 
• 389633-40-3 (1R,3R,4R,5R,7RS)-1-phenyl-3-(tert-butyldiphenylsilyloxymethyl)-4,7-diacetoxy-2,6-dioxabicylco[3.3.0]octane 
• 660410-57-1 (1'S,3'R,4'R,5'R,7'S)-N²-isobutyryl-9-(4'-hydroxy-3'-hydroxymethyl-1'-phenyl-2',6'-dioxabicyclo[3.3.0]oct-7'-yl)guanine 
• 389633-43-6 (1'S,3'R,4'R,5'R,7'R)-N²-isobutyryl-9-{4'-acetoxy-1'-phenyl-3'-(tert-butyldiphenylsilyloxymethyl)-2',6'-dioxabicyclo[3.3.0]oct-7'-yl}guanine 
• 389633-41-4 (1'S,3'R,4'R,5'R,7'S)-N²-isobutyryl-9-{4'-acetoxy-1'-phenyl-3'-(tert-butyldiphenylsilyloxymethyl)-2',6'-dioxabicyclo[3.3.0]oct-7'-yl}guanine 
• 389633-44-7 (1'S,3'R,4'R,5'R,7'R)-N²-isobutyryl-7-{4'-acetoxy-1'-phenyl-3'-(tert-butyldiphenylsilyloxymethyl)-2',6'-dioxabicyclo[3.3.0]oct-7'-yl}guanine 
• 389633-42-5 (1'S,3'R,4'R,5'R,7'S)-N²-isobutyryl-7-{4'-acetoxy-1'-phenyl-3'-(tert-butyldiphenylsilyloxymethyl)-2',6'-dioxabicyclo[3.3.0]oct-7'-yl}guanine 
• 32252-03-2 (-)-1'-deoxy-1'-phenyl-β-D-ribofuranose 

Relevant academic research and scientific papers

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

Synthesis of 1'-phenyl substituted nucleoside analogs

l'-Phenyl substituted ribonucleoside analogs with all four nucleobases have been synthesized by the conventional N-glycosidation method.

Selective Formation of Stable Triplexes Including a TA or a CG Interrupting Site with New Bicyclic Nucleoside Analogues (WNA)

Triplex-forming oligonucleotides (TFOs) are potential DNA-targeting molecules and would become powerful tools for genomic research. As the stabilization of the TFO is partially provided by hydrogen bonds to purine bases, the most stable triplexes form wit

W-shape nucleic acid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site

Novel nucleoside analogs have been designed for selective formation of anti-parallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex-forming oligodeoxynucleotide (TFO) incorporating the new analog, WNA-7βG, formed a stable triplex with high selectivity to the TA site.

Diastereoselective reduction of hemiacetals derived from 2,3-o-isopropylidene derivatives of carbohydrate lactones

Reactions of organomagnesium and/or organolithium reagents with 2,3-O-isopropylidene-D-erythronolactone and 5-O-tertbutyldiphenylsilyl-2,3-O-isopropylidene-D-ribonolactone gave good yields of the corresponding hemiacetals which, by choice of hydride reage

Modified Nucleosides for Ribozyme Structure-Activity Studies

C-Phenyl, C-p-aminophenyl and C-naphthyl as well as pyridine-4(2)-one ribofuranosides were synthesized and site-specifically incorporated into a hammerhead ribozyme using solid phase synthesis.The modified oligonucleotides were used to probe the structural requirements at position 7 for catalytic activity.A pyridine-4-one-base substitution at a single position (N7) within the ribozyme catalytic core increased catalytic rate 10-fold.C-Phenyl, N3-methyluracyl, and p-aminophenyl base substitution at N7 reproducibly increased the catalytic rate twofold.

A ribonolactone-based approach to the synthesis of 1'-carbon-substituted thymine ribonucleosides

Thymine ribonucleosides bearing a carbon substituent at the anomeric position were synthesized starting from D-ribonolactone by way of nucleophilic addition reaction of organolithium reagents and subsequent condensation with trimethylsilylated thymine.